Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.59 extracted from

  • Fraebel, S.; Krischke, M.; Staniek, A.; Warzecha, H.
    Recombinant flavin-dependent halogenases are functional in tobacco chloroplasts without co-expression of flavin reductase genes (2016), Biotechnol. J., 11, 1586-1594 .
    View publication on PubMed
Search for more literature for 1.14.19.59

Cloned(Commentary)

Cloned (Comment) Organism
gene stth, functional recombinant expression of Yfp-tagged enzyme in Nicotianan benthamiana leaves via Agrobacterium tumefaciens strain EHA105 tranfection method under control of the CaMV 35S promoter leading to formation of 6-chlorotryptophan, coexpression with gene rebF from Lechevalieria aerocolonigenes, different genetic constructs, overview. Coexpression and concerted activity of Stth and tryptophan 7-halogenase RebH, EC 1.14.19.9, lead to formation of 6,7-halotryptophan Streptomyces toxytricini

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7-chloro-L-tryptophan + FADH2 + chloride + O2 + H+ Streptomyces toxytricini
-
 6,7-dichloro-L-tryptophan + FAD + 2 H2O
-
 ?
L-tryptophan + FADH2 + chloride + O2 + H+ Streptomyces toxytricini
-
 6-chloro-L-tryptophan + FAD + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces toxytricini E9P162
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-chloro-L-tryptophan + FADH2 + chloride + O2 + H+
-
 Streptomyces toxytricini 6,7-dichloro-L-tryptophan + FAD + 2 H2O
-
 ?
L-tryptophan + FADH2 + chloride + O2 + H+
-
 Streptomyces toxytricini 6-chloro-L-tryptophan + FAD + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
sttH
-
 Streptomyces toxytricini

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Streptomyces toxytricini