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Literature summary for 1.14.19.3 extracted from

  • Shi, H.; Chen, H.; Gu, Z.; Zhang, H.; Chen, W.; Chen, Y.Q.
    Application of a delta-6 desaturase with alpha-linolenic acid preference on eicosapentaenoic acid production in Mortierella alpina (2016), Microb. Cell Fact., 15, 117 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant overexpression of MpFADS6 in a uracil-auxotrophic Mortierella alpina strain to enhance eicosapentaenoic acid production in Mortierella alpina by favoring the omega3 pathway, using the Agrobacterium tumefaciens-mediated transformation method. The expression of MpFADS6 results in a 26.2fold increase in EPA production compared to wild-type Mortierella alpina Micromonas pusilla

Protein Variants

Protein Variants Comment Organism
additional information recombinant overexpression of Micromonas pusilla strain CCMP 1545 enzyme MpFADS6 in a uracil-auxotrophic Mortierella alpina strain to enhance eicosapentaenoic acid production in Mortierella alpina by favoring the omega3 pathway, using the Agrobacterium tumefaciens-mediated transformation method. The expression of MpFADS6 results in a 26.2fold increase in EPA production compared to wild-type Mortierella alpina, fatty acid profile with addition of exogenous alpha-linolenoic acid. Further enhancement of EPA production with peony seed meal, overview Mortierella alpina

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mortierella alpina 16020
-
membrane
-
Micromonas pusilla 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Mortierella alpina
-
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Micromonas pusilla preferred substrate stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Mortierella alpina ATCC 32222
-
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Micromonas pusilla CCMP 1545 preferred substrate stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Micromonas pusilla
-
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Mortierella alpina preferred substrate gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Mortierella alpina ATCC 32222 preferred substrate gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Micromonas pusilla CCMP 1545
-
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
additional information Mortierella alpina polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels ?
-
?
additional information Mortierella alpina ATCC 32222 polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels ?
-
?

Organism

Organism UniProt Comment Textmining
Micromonas pusilla C1MKR5
-
-
Micromonas pusilla CCMP 1545 C1MKR5
-
-
Mortierella alpina Q70BL2
-
-
Mortierella alpina ATCC 32222 Q70BL2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information growth temperatures 12-28°C Mortierella alpina
-
mycelium
-
Mortierella alpina
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
Mortierella alpina stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ preferred substrate Micromonas pusilla stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
Mortierella alpina ATCC 32222 stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ preferred substrate Micromonas pusilla CCMP 1545 stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
Micromonas pusilla gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ preferred substrate Mortierella alpina gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ preferred substrate Mortierella alpina ATCC 32222 gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
Micromonas pusilla CCMP 1545 gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?
additional information polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels Mortierella alpina ?
-
?
additional information polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels Mortierella alpina ATCC 32222 ?
-
?

Synonyms

Synonyms Comment Organism
DELTA-6 desaturase
-
Mortierella alpina
DELTA-6 desaturase
-
Micromonas pusilla
delta61
-
Mortierella alpina
FADS6
-
Mortierella alpina
FADS6
-
Micromonas pusilla
MaFADS6
-
Mortierella alpina
MaFADS6-I
-
Mortierella alpina
MpFADS6
-
Micromonas pusilla

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
Mortierella alpina
cytochrome b5
-
Micromonas pusilla