Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae BY4741 cells | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Arabidopsis thaliana | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+ | Arabidopsis thaliana | - |
(4R,8E)-4-hydroxysphing-8-enine ceramide + (4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O | the ratio of trans:cis products is approximately 4:1 for isoform SLD1 and 7:1 for isoform SLD2 | ? | |
sphinganine ceramide + ferrocytochrome b5 + O2 + H+ | Arabidopsis thaliana | - |
8-sphingenine ceramide + ferricytochrome b5 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
ecotype Col-0 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
flower | isoform SLD1 and SLD2 are most highly expressed in the flower | Arabidopsis thaliana | - |
leaf | isoform SLD1 | Arabidopsis thaliana | - |
root | isoform SLD1 | Arabidopsis thaliana | - |
silique | isoform SLD1 and SLD2 | Arabidopsis thaliana | - |
stem | isoform SLD1 | Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+ | - |
Arabidopsis thaliana | (4R,8E)-4-hydroxysphing-8-enine ceramide + (4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O | the ratio of trans:cis products is approximately 4:1 for isoform SLD1 and 7:1 for isoform SLD2 | ? | |
sphinganine ceramide + ferrocytochrome b5 + O2 + H+ | - |
Arabidopsis thaliana | 8-sphingenine ceramide + ferricytochrome b5 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DELTA8 Des | - |
Arabidopsis thaliana |
LCB DELTA8 desaturase | - |
Arabidopsis thaliana |
SLD1 | isoform | Arabidopsis thaliana |
SLD2 | isoform | Arabidopsis thaliana |
sphingoid long-chain base DELTA8 desaturase | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deletion mutants reveal a 50% reduction in glucosylceramide levels and a corresponding increase in glycosylinositolphosphoceramides | Arabidopsis thaliana |