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Literature summary for 1.14.19.29 extracted from

  • Chen, M.; Markham, J.; Cahoon, E.
    Sphingolipid DELTA8 unsaturation is important for glucosylceramide biosynthesis and low-temperature performance in Arabidopsis (2012), Plant J., 69, 769-781.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae BY4741 cells Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Arabidopsis thaliana 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+ Arabidopsis thaliana
-
(4R,8E)-4-hydroxysphing-8-enine ceramide + (4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O the ratio of trans:cis products is approximately 4:1 for isoform SLD1 and 7:1 for isoform SLD2 ?
sphinganine ceramide + ferrocytochrome b5 + O2 + H+ Arabidopsis thaliana
-
8-sphingenine ceramide + ferricytochrome b5 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
ecotype Col-0
-

Source Tissue

Source Tissue Comment Organism Textmining
flower isoform SLD1 and SLD2 are most highly expressed in the flower Arabidopsis thaliana
-
leaf isoform SLD1 Arabidopsis thaliana
-
root isoform SLD1 Arabidopsis thaliana
-
silique isoform SLD1 and SLD2 Arabidopsis thaliana
-
stem isoform SLD1 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+
-
Arabidopsis thaliana (4R,8E)-4-hydroxysphing-8-enine ceramide + (4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O the ratio of trans:cis products is approximately 4:1 for isoform SLD1 and 7:1 for isoform SLD2 ?
sphinganine ceramide + ferrocytochrome b5 + O2 + H+
-
Arabidopsis thaliana 8-sphingenine ceramide + ferricytochrome b5 + H2O
-
?

Synonyms

Synonyms Comment Organism
DELTA8 Des
-
Arabidopsis thaliana
LCB DELTA8 desaturase
-
Arabidopsis thaliana
SLD1 isoform Arabidopsis thaliana
SLD2 isoform Arabidopsis thaliana
sphingoid long-chain base DELTA8 desaturase
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction enzyme deletion mutants reveal a 50% reduction in glucosylceramide levels and a corresponding increase in glycosylinositolphosphoceramides Arabidopsis thaliana