Literature summary for 1.14.19.25 extracted from

Pan, J.; Zhou, S.; Xiang, R.; Zhao, Z.; Liu, S.; Ding, N.; Gong, S.; Lin, Y.; Li, X.; Bai, X.; Li, F.; Zhao, A.Z.
An OMEGA-3 fatty acid desaturase-expressing gene attenuates prostate cancer proliferation by cell cycle regulation (2017), Oncol. Lett., 13, 3717-3721 .

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Application

Application	Comment	Organism
medicine	consuming high levels of long-chain OMEGA-3 polyunsaturated fatty acids (PUFAs) is been shown to reduce prostate cancer risk and increase chemotherapy sensitivity in humans	Saprolegnia diclina

Cloned(Commentary)

Cloned (Comment)	Organism
gene sdd17, recombinant exression of codon-otimized gene in human VCaP prostate cancer cells by lentiviral tranfection using the the PLJM1 lentivirus vector, which allows the endogenous production of OMEGA-3 polyunsaturated fatty acids (PUFAs), quantitative RT-PCR expression analysis	Saprolegnia diclina

Organism

Organism	UniProt	Comment	Textmining
Saprolegnia diclina	Q6UB73	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+	-	Saprolegnia diclina	eicosapentaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
msdd17	-	Saprolegnia diclina
omega-3 fatty acid desaturase	-	Saprolegnia diclina
sdd17	-	Saprolegnia diclina

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Saprolegnia diclina

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Saprolegnia diclina

General Information

General Information	Comment	Organism
physiological function	OMEGA-3 fatty acid desaturase converts exogenous arachidonic acid, an OMEGA-6 PUFA, into eicosapentaenoic acid (EPA). Gene sdd17 from EPA-rich fungus is expressed at high levels and increases OMEGA-3 fatty acid concentrations in mammalian cells	Saprolegnia diclina

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Release 2023.1 (January 2023)