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Literature summary for 1.14.19.17 extracted from

  • Ternes, P.; Franke, S.; Zaehringer, U.; Sperling, P.; Heinz, E.
    Identification and characterization of a sphingolipid delta 4-desaturase family (2002), J. Biol. Chem., 277, 25512-25518.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain sur2DELTA Caenorhabditis elegans
expressed in Saccharomyces cerevisiae strain sur2DELTA Homo sapiens
expressed in Saccharomyces cerevisiae strain sur2DELTA Mus musculus
expressed in Saccharomyces cerevisiae strain sur2DELTA Drosophila melanogaster
expressed in Saccharomyces cerevisiae strain sur2DELTA Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydroceramide + ferrocytochrome b5 + O2 + H+ Caenorhabditis elegans
-
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+ Mus musculus
-
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+ Drosophila melanogaster
-
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+ Candida albicans
-
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans G5EC63
-
-
Candida albicans Q5AJX2
-
-
Drosophila melanogaster Q94515
-
-
Homo sapiens O15121
-
-
Mus musculus O09005
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spermatocyte
-
Caenorhabditis elegans
-
spermatocyte
-
Homo sapiens
-
spermatocyte
-
Mus musculus
-
spermatocyte
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroceramide + ferrocytochrome b5 + O2 + H+
-
Caenorhabditis elegans (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+
-
Homo sapiens (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+
-
Mus musculus (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+
-
Drosophila melanogaster (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
dihydroceramide + ferrocytochrome b5 + O2 + H+
-
Candida albicans (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?

Synonyms

Synonyms Comment Organism
degenerative spermatocyte desaturase
-
Mus musculus
degenerative spermatocyte desaturase
-
Drosophila melanogaster
DES-1
-
Drosophila melanogaster
DES1
-
Caenorhabditis elegans
DES1
-
Homo sapiens
DES1
-
Mus musculus
DES1
-
Candida albicans
dihydroceramide desaturase
-
Caenorhabditis elegans
dihydroceramide desaturase
-
Homo sapiens
dihydroceramide desaturase
-
Mus musculus
dihydroceramide desaturase
-
Drosophila melanogaster
dihydroceramide desaturase
-
Candida albicans
MDES
-
Mus musculus
membrane lipid desaturase
-
Homo sapiens
MLD
-
Homo sapiens
sphingolipid DELTA4-desaturase
-
Caenorhabditis elegans
sphingolipid DELTA4-desaturase
-
Homo sapiens
sphingolipid DELTA4-desaturase
-
Mus musculus
sphingolipid DELTA4-desaturase
-
Drosophila melanogaster
sphingolipid DELTA4-desaturase
-
Candida albicans

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
Caenorhabditis elegans
cytochrome b5
-
Homo sapiens
cytochrome b5
-
Mus musculus
cytochrome b5
-
Drosophila melanogaster
cytochrome b5
-
Candida albicans

General Information

General Information Comment Organism
physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Caenorhabditis elegans
physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Homo sapiens
physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Mus musculus
physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Drosophila melanogaster
physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Candida albicans