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Literature summary for 1.14.19.1 extracted from

  • Chen, L.; Ren, J.; Yang, L.; Li, Y.; Fu, J.; Li, Y.; Tian, Y.; Qiu, F.; Liu, Z.; Qiu, Y.
    Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis (2016), Sci. Rep., 6, 19665 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.1

Cloned(Commentary)

Cloned (Comment) Organism
gene scd1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide i.e. A939 or A939572, an SCD1 inhibitor, causes significantly delayed tumor growth, which is reversed by L-cycloserine, an inhibitor of ceramide biosynthesis. A939 can significantly inhibit LOVO cell proliferation, which can be dose-dependently reversed by oleic acid, but not by palmitic acid Homo sapiens
Cay10566 i.e. Cay105 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum mainly Homo sapiens 5783
-
membrane transmembrane enzyme Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
 palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
 oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00767
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Colo-205 cell
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
LoVo cell colorectal adenocarcinoma cells Homo sapiens
-
additional information mRNA expression levels of SCD1 in tumor tissues markedly elevated compared to that in adjacent non-tumor tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
SCD1
-
 Homo sapiens
stearoyl-CoA desaturase 1
-
 Homo sapiens
stearoyl-CoA desaturase-1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction reduction of SCD1 activity and mRNA expression impaired the formation of cell membrane lipids with the decrease of fatty acid biosynthesis and desaturation, leading to cease cancer cell proliferation and induction of cell apoptosis. Inhibition of stearoyl-CoA desaturase 1 (SCD1) effectively suppresses tumor cell proliferation and induce apoptosis in numerous neoplastic lesions, SCD1-mediated anti-tumor effect. Endo-lipid messenger ceramides play a critical role in tumor fate modulated by SCD1 inhibition. Inhibition of SCD1 activity promotes apoptosis attributed to mitochondria dysfunctions, upregulation of reaction oxygen species (ROS), alteration of mitochondrial transmembrane potential, and translocation of mitochondrial protein cytochrome C in colorectal cancer cells. These effects are mediated by intracellular ceramide signals through induction of ceramide biosynthesis, rather than exclusive saturated fatty acid accumulation. Inhibitor A939 dramatically increases intracellular long-chain saturated ceramide levels including C18:0 ceramide, C20:0 ceramide, C22:0 ceramide, and C24:0 ceramide, while it slightly increases middle-chain saturated ceramide C16:0 and does not affect monounsaturated C24:1 ceramide Homo sapiens
metabolism cross-talk of SCD1-mediated lipid pathway and endo-ceramide biosynthesis pathway, indicating roles of ceramide signals in SCD1-mediated anti-tumor property Homo sapiens
physiological function stearoyl-CoA desaturase-1 (SCD1) catalyzes saturated fatty acids to DELTA-9 monounsaturated fatty acids, e.g. converting palmitic acid (C16:0) to palmitoleic acid (C16:1) or converting stearic acid (C18:0) to oleic acid (C18:1). SCD1 is necessary to stimulate lipid biosynthesis to supply new phospholipids for cell membrane biogenesis in cell cycle process of mitosis Homo sapiens