Literature summary for 1.14.19.1 extracted from

Rodriguez-Cuenca, S.; Whyte, L.; Hagen, R.; Vidal-Puig, A.; Fuller, M.
Stearoyl-CoA desaturase 1 Is a key determinant of membrane lipid composition in 3T3-L1 adipocytes (2016), PLoS ONE, 11, e0162047 .

Search for more literature for 1.14.19.1

Cloned(Commentary)

Cloned (Comment)	Organism
gene scd1, real-time PCR expression analysis	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	scd1 gene silencing by siRNA resulting in 90% reduction in scd1 mRNA expression, ceramide spectrum in the mutant, membrane microdomain lipid and acyl chain composition are altered in SCD1 knockdown mutant cells, phenotype, overview. Short range lateral diffusion, using 1-pyrenedecanoic acid, is highly reduced in mutant cell membranes. SCD1 knockout activates the expression of enzymes involved in the remodelling of phospholipids	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Mus musculus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	SCD1 catalyses the DELTA9 desaturation of 12-19 carbon saturated fatty acids to monounsaturated fatty acids	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P13516	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	-	Mus musculus	-
adipocyte	-	Mus musculus	-
liver	-	Mus musculus	-
additional information	the enzyme is highly expressed in lipogenic tissues, such as liver and adipose tissue	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	SCD1 catalyses the DELTA9 desaturation of 12-19 carbon saturated fatty acids to monounsaturated fatty acids	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
DELTA9 desaturase	-	Mus musculus
SCD1	-	Mus musculus
stearoyl-CoA desaturase 1	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	dysregulation of stearoyl-CoA desaturase 1 likely contributes to obesity associated metabolic disturbances. Effect of genetic ablation of SCD1 in 3T3-L1 adipocytes on membrane microdomain lipid composition at the species-specific level, overview. 90% reduction in scd1 mRNA expression, caused by siRNA expression, leads to altered cellular lipid composition, SCD1 knockout modifies the acyl chain composition of lipids, as well as the lipid composition per se of membrane microdomains in 3T3-L1 adipocytes.The effects of SCD1 knockout are not limited to alterations in 16:0 and 18:0 fatty acids. Cholesterol content is unchanged although decreases in other lipids result in cholesterol accounting for a higher proportion of lipid in the membranes. This is associated with decreased membrane lateral diffusion. An increased ratio of 24:0 to 24:1 in ceramide, mono- and dihexosylceramide, and sphingomyelin likely also contributes to this decrease in lateral diffusion. Lipidomic profiling is targeted to specific membrane microdomains, overview. A decrease in phospholipids containing arachidonic acid is observed. Given the high degree of structural flexibility of this acyl chain this will influence membrane lateral diffusion, and is likely responsible for the transcriptional activation of Lands' cycle enzymes lpcat3 and mboat7	Mus musculus
physiological function	stearoyl-CoA desaturase 1 is a lipogenic enzyme important for the regulation of membrane lipid homeostasis. The enzyme catalyses the insertion of a cis double bond in 12-19 carbon saturated fatty acids, thereby converting them to monounsaturated fatty acids. Through this activity, SCD1 helps to regulate the ratio of saturated to monounsaturated acyl chains in membrane lipids influencingmembrane fluidity and functionality, both essential for maintaining cellular integrity. Adaptive homeostatic mechanisms to ensure partial maintenance of the biophysical properties of membranes likely occur at a post-transcriptional level	Mus musculus

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Release 2023.1 (January 2023)