Literature summary for 1.14.19.1 extracted from

Ma, M.K.F.; Lau, E.Y.T.; Leung, D.H.W.; Lo, J.; Ho, N.P.Y.; Cheng, L.K.W.; Ma, S.; Lin, C.H.; Copland, J.A.; Ding, J.; Lo, R.C.L.; Ng, I.O.L.; Lee, T.K.W.
Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation (2017), J. Hepatol., 67, 979-990 .

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Application

Application	Comment	Organism
medicine	targeting SCD1 in combination with sorafenib may be another therapeutic strategy against liver cancer. SCD1 may be a biomarker for sorafenib response and personalized medicine for hepatocellular carcinoma	Homo sapiens
pharmacology	targeting SCD1 in combination with sorafenib may be another therapeutic strategy against liver cancer. Clinically, SCD1 serves as a good predictive marker for patient responses to sorafenib treatment. Targeting SCD1 synergizes the effect of sorafenib both in vitro and in vivo	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene scd, lentiviral-based overexpression and knockdown of SCD in tumor-initiating cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
A939572	an SCD inhibitor, pharmacological inhibition of SCD1 by A939572 suppresses selfrenewal, migration, invasion and sorafenib resistance of hepatocellular carcinoma cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00767	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocellular carcinoma cell	enzyme SCD1 is upregulated in enriched liver tumor-initiating cell populations and sporadically expressed in human hepatocellular carcinoma specimens, elevated SCD1 expression in hepatocellular carcinoma tumors	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-
liver	-	Homo sapiens	-
liver cancer cell	upregulation of SCD1 of self-renewing liver cancer cells in chemoresistant hepatospheres	Homo sapiens	-
PLC/PRF/5 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SCD1	-	Homo sapiens
stearoyl-CoA desaturase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme SCD1 is 28fold upregulated in enriched liver tumor-initiating cell populations and sporadically expressed in human hepatocellular carcinoma specimens, upregulation of SCD1 of self-renewing liver cancer cells in chemoresistant hepatospheres	up

General Information

General Information	Comment	Organism
malfunction	targeting SCD1 synergizes the effect of sorafenib both in vitro and in vivo. The endoplasmic reticulum stress-induced unfolded protein response is upregulated in SCD1-knockdown cells. Suppression of SCD1 forces liver cancer stem cells to differentiate via the induction of endoplasmic reticulum stress, which results in their enhanced sensitivity to sorafenib both in vitro and in vivo. SCD1 knockdown reduces stem/progenitor characteristics of hepatocellular carcinoma cells	Homo sapiens
physiological function	stearoyl-CoA desaturase regulates liver tumorinitiating cells and resistance to sorafenib, a drug in treatment of hepatocellular carcinoma, via modulation of endoplasmic reticulum stress-induced differentiation, functional roles of SCD1 in regulating liver tumor-initiating cells and sorafenib resistance, SCD1 maintains liver tumor-initiating cells by suppressing differentiation intervening in the differentiation process, overview	Homo sapiens

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Release 2023.1 (January 2023)