Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)pyrrolidin-2-one | - |
Homo sapiens | |
1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)pyrrolidin-2-one | - |
Rattus norvegicus | |
1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)urea | - |
Rattus norvegicus | |
1-[5-(1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Homo sapiens | |
1-[5-(1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Rattus norvegicus | |
1-[5-(1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Homo sapiens | |
1-[5-(1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Rattus norvegicus | |
1-[5-(1,3-oxazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Homo sapiens | |
1-[5-(1,3-oxazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Rattus norvegicus | |
1-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Homo sapiens | |
1-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Rattus norvegicus | |
1-[5-(5-methyl-1,3,4-thiadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | - |
Rattus norvegicus | |
2-(4-[[2-(trifluoromethyl)phenyl]sulfanyl]piperidin-1-yl)-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-(4-[[2-(trifluoromethyl)phenyl]sulfanyl]piperidin-1-yl)-1,3-thiazole-5-carboxamide | - |
Rattus norvegicus | |
2-[(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-[(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]-1,3-thiazole-5-carboxamide | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)benzyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)benzyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-4-carboxamide | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-4-carboxamide | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-carboxamide | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-sulfonamide | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-sulfonamide | - |
Rattus norvegicus | |
3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2,4-oxadiazole-5-carboxamide | - |
Rattus norvegicus | |
3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2-oxazole-5-carboxamide | - |
Homo sapiens | |
3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2-oxazole-5-carboxamide | - |
Rattus norvegicus | |
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-oxadiazole-2-carboxamide | - |
Homo sapiens | |
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-oxadiazole-2-carboxamide | - |
Rattus norvegicus | |
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazole-2-carboxamide | - |
Homo sapiens | |
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazole-2-carboxamide | - |
Rattus norvegicus | |
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1H-1,2,4-triazole-3-carboxamide | - |
Homo sapiens | |
5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1H-1,2,4-triazole-3-carboxamide | - |
Rattus norvegicus | |
methyl (2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)carbamate | - |
Homo sapiens | |
methyl (2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)carbamate | - |
Rattus norvegicus | |
[3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | - |
Homo sapiens | |
[3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
stearoyl-CoA desaturase | - |
Homo sapiens |
stearoyl-CoA desaturase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | |
0.000001 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | [3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | |
0.000003 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000003 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazole-2-carboxamide | |
0.000004 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(4-[[2-(trifluoromethyl)phenyl]sulfanyl]piperidin-1-yl)-1,3-thiazole-5-carboxamide | |
0.000004 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-[5-(1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000007 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazole-2-carboxamide | |
0.000008 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2-oxazole-5-carboxamide | |
0.00001 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000012 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000014 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2-oxazole-5-carboxamide | |
0.000014 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-[5-(1,3-oxazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000015 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000016 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-[5-(1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000024 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(4-[[2-(trifluoromethyl)phenyl]sulfanyl]piperidin-1-yl)-1,3-thiazole-5-carboxamide | |
0.000034 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-[5-(1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000039 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000041 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-sulfonamide | |
0.000055 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-[5-(1,3-oxazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000065 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-[5-(1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000076 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)benzyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000083 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-oxadiazole-2-carboxamide | |
0.000084 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000106 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000127 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1H-1,2,4-triazole-3-carboxamide | |
0.00015 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)urea | |
0.000153 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)benzyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000164 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)pyrrolidin-2-one | |
0.000174 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)pyrrolidin-2-one | |
0.000199 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-oxadiazole-2-carboxamide | |
0.000254 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000676 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-4-carboxamide | |
0.00075 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | methyl (2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)carbamate | |
0.00075 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-[5-(5-methyl-1,3,4-thiadiazol-2-yl)-1,3-thiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine | |
0.000775 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | methyl (2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)carbamate | |
0.001019 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-5-sulfonamide | |
0.001634 | - |
rat liver microsomal enzyme assay, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 3-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,2,4-oxadiazole-5-carboxamide | |
0.002823 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1H-1,2,4-triazole-3-carboxamide | |
0.006523 | - |
HepG2 whole cell assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazole-4-carboxamide |