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Literature summary for 1.14.19.1 extracted from

  • Reh, R.; Ozols, J.; Clement, B.
    Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs (2008), Xenobiotica, 38, 1177-1190.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cytochrome c
-
Rattus norvegicus
cytochrome c very low inhibitor concentrations of 10 mM lead to an almost complete inhibition of the SCD benzamidoxime reductase activity of porcine adipose tissue microsome Sus scrofa
p-hydroxymercuribenzoate
-
Rattus norvegicus
p-hydroxymercuribenzoate potent inhibitor of the SCD benzamidoxime reductase activity of porcine adipose tissue microsomes Sus scrofa
potassium cyanide
-
Rattus norvegicus
potassium cyanide supplementation of potassium cyanide leads to a 65% inhibition of the microsomal benzamidoxime reductase activity of SCD in porcine adipose tissue Sus scrofa
potassium hexacyanoferrate
-
Rattus norvegicus
potassium hexacyanoferrate
-
Sus scrofa
stearoyl-CoA inhibits SCD activity in concentrations greater than 0.05 mM Rattus norvegicus
stearoyl-CoA inhibits SCD activity in concentrations greater than 0.05 mM Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
microsome
-
Sus scrofa
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
SDS-PAGE Rattus norvegicus
41000
-
SDS-PAGE Sus scrofa

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Rattus norvegicus
-
adipose tissue
-
Sus scrofa
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-hydroxy-benzenecarboximidamide + NADH + H+ + O2
-
Rattus norvegicus benzamidine + NAD+ + H2O
-
?
N-hydroxy-benzenecarboximidamide + NADH + H+ + O2
-
Sus scrofa benzamidine + NAD+ + H2O
-
?
stearoyl-CoA + NADH + H+ + O2
-
Rattus norvegicus oleoyl-CoA + NAD+ + H2O
-
?
stearoyl-CoA + NADH + H+ + O2
-
Sus scrofa oleoyl-CoA + NAD+ + H2O
-
?

Subunits

Subunits Comment Organism
? x * 37000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
SCD
-
Rattus norvegicus
SCD
-
Sus scrofa
stearoyl-CoA desaturase
-
Rattus norvegicus
stearoyl-CoA desaturase
-
Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0000019
-
N-hydroxy-benzenecarboximidamide at 37°C Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADH
-
Rattus norvegicus
NADH
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0018
-
at 37°C Sus scrofa cytochrome c
0.2
-
at 37°C Sus scrofa stearoyl-CoA
0.229
-
at 37°C Sus scrofa potassium hexacyanoferrate
0.3
-
at 37°C Sus scrofa potassium cyanide