Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cis-9,trans-11 conjugated linoleic acid | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + NADH + H+ + O2 | - |
Mus musculus | oleoyl-CoA + NAD+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD1 | - |
Mus musculus |
stearoyl-CoA desaturase-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | hepatic SCD1 expression increases in experimental steatosis resulting from high fat diet and decreases in a methionine-choline-deficient dietary model of steatohepatitis resulting in the latter situation in significantly increased hepatic saturated fatty acid levels | up |
General Information | Comment | Organism |
---|---|---|
physiological function | SCD1 knockout mice on the methionine-choline-deficient diet have decreased steatosis and markedly increased hepatocellular apoptosis, liver injury, and fibrosis compared with the SCD-expressing mice | Mus musculus |