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Literature summary for 1.14.19.1 extracted from

  • Li, Z.Z.; Berk, M.; McIntyre, T.M.; Feldstein, A.E.
    Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase (2009), J. Biol. Chem., 284, 5637-5644.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
cis-9,trans-11 conjugated linoleic acid
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + NADH + H+ + O2
-
Mus musculus oleoyl-CoA + NAD+ + H2O
-
?

Synonyms

Synonyms Comment Organism
SCD1
-
Mus musculus
stearoyl-CoA desaturase-1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus hepatic SCD1 expression increases in experimental steatosis resulting from high fat diet and decreases in a methionine-choline-deficient dietary model of steatohepatitis resulting in the latter situation in significantly increased hepatic saturated fatty acid levels up

General Information

General Information Comment Organism
physiological function SCD1 knockout mice on the methionine-choline-deficient diet have decreased steatosis and markedly increased hepatocellular apoptosis, liver injury, and fibrosis compared with the SCD-expressing mice Mus musculus