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Literature summary for 1.14.19.1 extracted from

  • Soulard, P.; McLaughlin, M.; Stevens, J.; Connolly, B.; Coli, R.; Wang, L.; Moore, J.; Kuo, M.S.; LaMarr, W.A.; Ozbal, C.C.; Bhat, B.G.
    Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry (2008), Anal. Chim. Acta, 627, 105-111.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
linoleic acid
-
 Rattus norvegicus
Sterculic acid
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0105
-
 stearoyl-CoA in 150 mM KCl, 40 mM NaF, 100 mM sodium phosphate buffer, pH 7.4, at 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + ferrocytochrome b5 + O2
-
 Rattus norvegicus oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?
stearoyl-CoA + NADH + H+ + O2
-
 Rattus norvegicus oleoyl-CoA + NAD+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
SCD1
-
 Rattus norvegicus
stearoyl-CoA desaturase 1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Rattus norvegicus
NADH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00012
-
 in 150 mM KCl, 40 mM NaF, 100 mM sodium phosphate buffer, pH 7.4, at 37°C Rattus norvegicus Sterculic acid
0.00088
-
 in 150 mM KCl, 40 mM NaF, 100 mM sodium phosphate buffer, pH 7.4, at 37°C Rattus norvegicus conjugated linoleic acid