Application | Comment | Organism |
---|---|---|
medicine | potential use of SCD1 as a target in the treatment of some eye diseases | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids | ? | - |
? | |
palmitoyl-CoA + AH2 + O2 | Mus musculus | - |
palmitoleoyl-CoA + A + H2O | - |
? | |
stearoyl-CoA + AH2 + O2 | Mus musculus | - |
oleoyl-CoA + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | existence of three highly homologous isoforms: SCD1, SCD2 and SCD3 which show different substrate specificities, here SCD1 is mainly analysed | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose | contains high amounts | Mus musculus | - |
brain | - |
Mus musculus | - |
eye | ball | Mus musculus | - |
gland | contains high amounts | Mus musculus | - |
liver | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SCD2 and SCD3 preferentially utilize palmitoyl-CoA | Mus musculus | ? | - |
? | |
additional information | rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids | Mus musculus | ? | - |
? | |
palmitoyl-CoA + AH2 + O2 | - |
Mus musculus | palmitoleoyl-CoA + A + H2O | - |
? | |
palmitoyl-CoA + NADH + O2 | - |
Mus musculus | palmitoleoyl-CoA + NAD+ + H2O | - |
? | |
stearoyl-CoA + AH2 + O2 | - |
Mus musculus | oleoyl-CoA + A + H2O | - |
? | |
stearoyl-CoA + NADH + O2 | preferred substrate for SCD1 | Mus musculus | oleoyl-CoA + NAD+ + H2O | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
23 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mus musculus |