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Literature summary for 1.14.18.B1 extracted from

  • Na, J.; Lee, K.; Na, W.; Shin, J.; Lee, M.; Yune, T.; Lee, H.; Jung, H.; Kim, W.; Ju, B.
    Histone H3K27 demethylase JMJD3 in cooperation with NF-kappaB regulates keratinocyte wound healing (2016), J. Invest. Dermatol., 136, 847-858 .
No PubMed abstract available
Search for more literature for 1.14.18.B1

Application

Application Comment Organism
medicine regulation of JMJD3 may provide a therapeutic intervention for treating the chronic skin wounds Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene KDM6B or JMJD3, quantitative PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 Homo sapiens
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 histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15054
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
keratinocyte epidermal keratinocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
histone H3K27 demethylase
-
 Homo sapiens
JmjC domain-containing protein 3 UniProt Homo sapiens
JMJD3
-
 Homo sapiens
Jumonji domain-containing protein 3 UniProt Homo sapiens
KDM6B
-
 Homo sapiens
lysine demethylase 6B UniProt Homo sapiens

Expression

Organism Comment Expression
Homo sapiens upregulation of JMJD3 expression in scratch-wounded keratinocytes up

General Information

General Information Comment Organism
malfunction inactivation of JMJD3 or NF-kappaB results in aberrant keratinocyte wound healing Homo sapiens
physiological function histone H3K27 demethylase JMJD3 is involved in diverse biological processes such as animal development, inflammation, senescence, and apoptosis. Histone H3K27me3 demethylase JMJD3 is involved in keratinocyte differentiation andwound healing. Enzyme JMJD3 upregulation and NF-kappaB activation occur in the region of the wound edge during keratinocyte wound healing. JMJD3 interacts with NF-kappaB, resulting in increased expression of the inflammatory, matrix metalloproteinase, and growth factor genes via demethylation of H3K27me3 at the gene promoters Homo sapiens