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Literature summary for 1.14.18.9 extracted from

  • Wang, Y.; Muneton, S.; Sjoevall, J.; Jovanovic, J.N.; Griffiths, W.J.
    The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome (2008), J. Proteome Res., 7, 1606-1614.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information (24S)-hydroxycholesterol downregulates the expression of several members of the cholesterol/isoprenoid synthesis pathways including the methylsterol monooxygenase, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in cholesterol biosynthesis, (24S)-hydroxycholesterol downregulates cholesterol synthesis in neurons, possibly, in a posttranscriptional manner through SREBP-2, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
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neuron
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in cholesterol biosynthesis, (24S)-hydroxycholesterol downregulates cholesterol synthesis in neurons, possibly, in a posttranscriptional manner through SREBP-2, overview Homo sapiens ?
-
 ?