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Literature summary for 1.14.18.9 extracted from

  • Mo, C.; Bard, M.
    Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex (2005), J. Lipid Res., 46, 1991-1998.
    View publication on PubMed
Search for more literature for 1.14.18.9

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane the enzyme forms a demethylation complex in the ER together with the transmembrane protein Erg28p, and possibly the other C-4 demethylation proteins Erg26p, overview Saccharomyces cerevisiae 5789
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additional information subcellular localization study Saccharomyces cerevisiae
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4,4-dimethyl-zymosterol + reduced acceptor + O2 Saccharomyces cerevisiae a step in the ergosterol biosynthesis, pathway, overview 4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,4-dimethyl-zymosterol + reduced acceptor + O2
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 Saccharomyces cerevisiae 4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
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 ?
4,4-dimethyl-zymosterol + reduced acceptor + O2 a step in the ergosterol biosynthesis, pathway, overview Saccharomyces cerevisiae 4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
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 ?
additional information the enzyme is closely associated to Erg28p Saccharomyces cerevisiae ?
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 ?

Synonyms

Synonyms Comment Organism
ERG25p
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 Saccharomyces cerevisiae
sterol C-4 methyloxidase
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 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADPH
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 Saccharomyces cerevisiae