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Literature summary for 1.14.18.7 extracted from

  • Nagano, M.; Takahara, K.; Fujimoto, M.; Tsutsumi, N.; Uchimiya, H.; Kawai-Yamada, M.
    Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses (2012), Plant Physiol., 159, 1138-1148.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O48916 isoform FAH1
-
Arabidopsis thaliana Q9SUC5 isoform FAH2
-

Synonyms

Synonyms Comment Organism
FAH1
-
 Arabidopsis thaliana
FAH2
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH1 mainly 2-hydroxylates very-long-chain fatty acids. In FAH1 knock-down lines, levels of hydroxylated fatty acids 22:0, 24:0, and 26:0 are considerably lower than in wild type, whereas the level of hydroxylated fatty acid 16:0 is marginally decreased. 2-Hydroxyfatty acids are related to resistance to oxidative stress, and isoform FAH1 or 2-hydroxy very-long-chain fatty acids show particularly strong responses to oxidative stress. Isoform FAH1 interacts with Bax inhibitor-1 via cytochrome b5 and is a key factor in Bax inhibitor-1-mediated cell death suppression Arabidopsis thaliana
physiological function interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH2 selectively 2-hydroxylates palmitic acid in Arabidopsis. In FAH2 knock-down lines, the level of hydroxylated fatty acid 16:0 is reduced by 22.9%, whereas the levels of other 2-hydroxyfatty acids are similar to those in wild type Arabidopsis thaliana