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Literature summary for 1.14.18.6 extracted from

  • Guo, L.; Zhang, X.; Zhou, D.; Okunade, A.; Su, X.
    Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers (2012), J. Lipid Res., 53, 1327-1335.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7L5A8
-
-
Mus musculus Q5MPP0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information FA2H is stereospecific for the production of (R)-enantiomers Mus musculus ?
-
?
additional information initiates fatty acid alpha-oxidation and is also responsible for the biosynthesis of 2-hydroxy fatty acid-containing sphingolipids in mammalian cells Homo sapiens ?
-
?
palmitic acid + 2 ferrocytochrome b5 + O2 + 2 H+
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Homo sapiens (R)-2-hydroxypalmitic acid + 2 ferricytochrome b5 + H2O FA2H is stereospecific for the production of (R)-enantiomers ?

General Information

General Information Comment Organism
physiological function FA2H knockdown in adipocytes increases diffusional mobility of raft-associated lipids, leading to reduced GLUT4 protein level, glucose uptake, and lipogenesis Mus musculus