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Literature summary for 1.14.18.5 extracted from

  • Grilley, M.; Stock, S.; Dickson, R.; Lester, R.; Takemoto, J.
    Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae (1998), J. Biol. Chem., 273, 11062-11068.
    View publication on PubMed
Search for more literature for 1.14.18.5

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Saccharomyces cerevisiae 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron a diiron binding enzyme Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae W303C
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroceramide + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae ?
-
 ?
dihydroceramide + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae W303C ?
-
 ?
DL-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae phytosphingosine + acceptor + H2O
-
 ?
DL-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
-
 Saccharomyces cerevisiae W303C phytosphingosine + acceptor + H2O
-
 ?

Synonyms

Synonyms Comment Organism
DHS hydroxylase
-
 Saccharomyces cerevisiae
dihydroceramide hydrolase
-
 Saccharomyces cerevisiae
SUR2
-
 Saccharomyces cerevisiae
SYR2
-
 Saccharomyces cerevisiae
Syr2p
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction yeast strains deficient in Syr2 lack the sphingoid long chain base phytosphingosine Saccharomyces cerevisiae
physiological function SYR2 is necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E. The SYR2 gene is required for the 4-hydroxylation reaction of sphingolipid long chain bases and is not essential for growth. SYR2 does not play a role in sterol biosynthesis Saccharomyces cerevisiae