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Literature summary for 1.14.18.12 extracted from

  • Seki, N.; Mori, K.; Kitamura, T.; Miyamoto, M.; Kihara, A.
    Yeast Mpo1 is a novel dioxygenase that catalyzes the alpha-oxidation of a 2-hydroxy fatty acid in an Fe2+-dependent manner (2019), Mol. Cell. Biol., 39, e00428-18 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.18.12

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0159
-
 (2R)-2-hydroxypalmitic acid 37°C, pH not specified in the publication Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for enzyme function Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2R)-2-hydroxypalmitic acid + O2 Saccharomyces cerevisiae the enzyme is involved in the alpha-oxidation of 2-hydroxypalmitic acid (C16:0-COOH) in the phytosphingosine metabolic pathway pentadecanoic acid + H2O + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R)-2-hydroxypalmitic acid + O2
-
 Saccharomyces cerevisiae pentadecanoic acid + H2O + CO2
-
 ?
(2R)-2-hydroxypalmitic acid + O2 the enzyme is involved in the alpha-oxidation of 2-hydroxypalmitic acid (C16:0-COOH) in the phytosphingosine metabolic pathway Saccharomyces cerevisiae pentadecanoic acid + H2O + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MPO1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the enzyme is involved in the alpha-oxidation of 2-hydroxypalmitic acid (C16:0-COOH) in the phytosphingosine metabolic pathway. Phytosphingosine metabolism via the Mpo1-dependent pathway is important for proper ER stress response Saccharomyces cerevisiae