Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | non-heme iron-requiring enzyme | Aspergillus fumigatus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | - |
- |
- |
Aspergillus fumigatus CEA17 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methyl fecosterol + 6 ferricytochrome b5 + 3 O2 + 6 H+ | i.e. 4,24-dimethyl-cholesta-8,24(28)-dien-3beta-ol | Aspergillus fumigatus | 4,4-dimethyl fecosterol + 6 ferrocytochrome b5 + 4 H2O | - |
? | |
4-methyl fecosterol + 6 ferricytochrome b5 + 3 O2 + 6 H+ | i.e. 4,24-dimethyl-cholesta-8,24(28)-dien-3beta-ol | Aspergillus fumigatus CEA17 | 4,4-dimethyl fecosterol + 6 ferrocytochrome b5 + 4 H2O | - |
? | |
parkeol + 6 ferricytochrome b5 + 3 O2 + 6 H+ | i.e. 4,4,14-trimethyl-cholesta-9(11),24-dien-3beta-ol | Aspergillus fumigatus | 9(11)-dehydroergosterol + 6 ferrocytochrome b5 + 4 H2O | - |
? | |
parkeol + 6 ferricytochrome b5 + 3 O2 + 6 H+ | i.e. 4,4,14-trimethyl-cholesta-9(11),24-dien-3beta-ol | Aspergillus fumigatus CEA17 | 9(11)-dehydroergosterol + 6 ferrocytochrome b5 + 4 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C4-sterol methyl oxidase | - |
Aspergillus fumigatus |
Erg25A | isoform | Aspergillus fumigatus |
Erg25B | isoform | Aspergillus fumigatus |
SMO | - |
Aspergillus fumigatus |
General Information | Comment | Organism |
---|---|---|
malfunction | a erg25A deletion strain displays moderate susceptibility to hypoxia and the endoplasmic reticulum stress-inducing agent dithiothreitol, but is not required for virulence in murine or insect models of invasive aspergillosis | Aspergillus fumigatus |
physiological function | isoform Erg25A is not required for virulence of Aspergillus fumigatus | Aspergillus fumigatus |