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Literature summary for 1.14.18.10 extracted from

  • Blosser, S.; Merriman, B.; Grahl, N.; Chung, D.; Cramer, R.
    Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus (2014), Microbiology, 160, 2492-2506 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Iron non-heme iron-requiring enzyme Aspergillus fumigatus

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-
Aspergillus fumigatus CEA17
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methyl fecosterol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,24-dimethyl-cholesta-8,24(28)-dien-3beta-ol Aspergillus fumigatus 4,4-dimethyl fecosterol + 6 ferrocytochrome b5 + 4 H2O
-
?
4-methyl fecosterol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,24-dimethyl-cholesta-8,24(28)-dien-3beta-ol Aspergillus fumigatus CEA17 4,4-dimethyl fecosterol + 6 ferrocytochrome b5 + 4 H2O
-
?
parkeol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,4,14-trimethyl-cholesta-9(11),24-dien-3beta-ol Aspergillus fumigatus 9(11)-dehydroergosterol + 6 ferrocytochrome b5 + 4 H2O
-
?
parkeol + 6 ferricytochrome b5 + 3 O2 + 6 H+ i.e. 4,4,14-trimethyl-cholesta-9(11),24-dien-3beta-ol Aspergillus fumigatus CEA17 9(11)-dehydroergosterol + 6 ferrocytochrome b5 + 4 H2O
-
?

Synonyms

Synonyms Comment Organism
C4-sterol methyl oxidase
-
Aspergillus fumigatus
Erg25A isoform Aspergillus fumigatus
Erg25B isoform Aspergillus fumigatus
SMO
-
Aspergillus fumigatus

General Information

General Information Comment Organism
malfunction a erg25A deletion strain displays moderate susceptibility to hypoxia and the endoplasmic reticulum stress-inducing agent dithiothreitol, but is not required for virulence in murine or insect models of invasive aspergillosis Aspergillus fumigatus
physiological function isoform Erg25A is not required for virulence of Aspergillus fumigatus Aspergillus fumigatus