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Literature summary for 1.14.18.1 extracted from

  • Lien, C.Y.; Chen, C.Y.; Lai, S.T.; Chan, C.F.
    Kinetics of mushroom tyrosinase and melanogenesis inhibition by N-acetyl-pentapeptides (2014), ScientificWorldJournal, 2014, 409783 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Ac-KSRFR N-acetyl-pentapeptide Ac-P2, mixed-type inhibition Agaricus bisporus
Ac-KSSFR N-acetyl-pentapeptide Ac-P3, mixed-type inhibition Agaricus bisporus
Ac-RSRFK N-acetyl-pentapeptide Ac-P1, mixed-type inhibition Agaricus bisporus
Ac-RSRFS N-acetyl-pentapeptide Ac-P4, mixed-type inhibition Agaricus bisporus
kojic acid
-
Agaricus bisporus
additional information mushroom tyrosinase and melanogenesis inhibition by N-acetyl-pentapeptides, inhibition kinetics, overview. The compounds inhibits melanogenesis and reduce the melanin content, e.g. in murine B16F10 cells Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-dopa + O2 Agaricus bisporus
-
2 dopaquinone + 2 H2O
-
?
tyrosine + O2 Agaricus bisporus
-
dopaquinone + H2O
-
?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-dopa + O2
-
Agaricus bisporus 2 dopaquinone + 2 H2O
-
?
tyrosine + O2
-
Agaricus bisporus dopaquinone + H2O
-
?

Synonyms

Synonyms Comment Organism
mushroom tyrosinase
-
Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, kinetic analysis of N-acetyl-pentapeptides, overview Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00029
-
pH 6.8, 25°C Agaricus bisporus Ac-RSRFS
0.00075
-
pH 6.8, 25°C Agaricus bisporus Ac-RSRFK
0.00078
-
pH 6.8, 25°C Agaricus bisporus Ac-KSRFR
0.00081
-
pH 6.8, 25°C Agaricus bisporus Ac-KSSFR