Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.18.1 extracted from

  • Zheng, J.; Zhang, R.; Chen, Y.; Ye, X.; Chen, Q.; Shen, D.; Wang, Q.
    Synthesis of caffeic acid ester morpholines and their activation effects on tyrosinase (2017), Process Biochem., 62, 91-98 .
No PubMed abstract available
Search for more literature for 1.14.18.1

Activating Compound

Activating Compound Comment Organism Structure
2-morpholinoethyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(2-hydroxyethyl) morpholine ester, activates mushroom tyrosinase activity dramatically, the activation of mushroom tyrosinase is noncompetitive Agaricus bisporus
2-morpholinoethyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(2-hydroxyethyl) morpholine ester, increases tyrosinase activity in M14 cells in a dose-dependent manner Homo sapiens
3-morpholinopropyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(2-hydroxyethyl) morpholine ester, increases tyrosinase activity in M14 cells in a dose-dependent manner Homo sapiens
3-morpholinopropyl (E)-3-(3,4-dihydroxyphenyl)acrylate a caffeic acid-4-(3-hydroxypropyl) morpholine ester, activates mushroom tyrosinase activity dramatically the activation of mushroom tyrosinase is noncompetitive Agaricus bisporus

Inhibitors

Inhibitors Comment Organism Structure
additional information synthesis of caffeic acid ester morpholines and inhibitory effect on tyrosinase Agaricus bisporus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a copper-containing enzyme Agaricus bisporus
Cu2+ a copper-containing enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?
2 L-dopa + O2 Homo sapiens
-
 2 dopaquinone + 2 H2O
-
 ?
tyrosine + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?
tyrosine + O2 Homo sapiens
-
 dopaquinone + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-
Homo sapiens P14679
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Agaricus bisporus
-
HL-7702 cell
-
 Homo sapiens
-
M14 cell
-
 Homo sapiens
-
melanocyte
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?
2 L-dopa + O2
-
 Homo sapiens 2 dopaquinone + 2 H2O
-
 ?
tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
tyrosine + O2
-
 Homo sapiens dopaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
mushroom tyrosinase
-
 Agaricus bisporus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Agaricus bisporus
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Agaricus bisporus
6.8
-
 assay at Homo sapiens