Literature summary for 1.14.18.1 extracted from

Ashraf, Z.; Rafiq, M.; Nadeem, H.; Hassan, M.; Afzal, S.; Waseem, M.; Afzal, K.; Latip, J.
Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies (2017), PLoS ONE, 12, e0178069 .

Search for more literature for 1.14.18.1

Inhibitors

Inhibitors	Comment	Organism	Structure
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(2,4-dihydroxyphenyl)prop-2-enoate	non-competitive inhibitor, binding to the enzyme's binuclear active site is irreversible. The 2-hydroxy group in the compound interacts with amino acid HIS85 which is present in active binding site	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate	-	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate	mixed-type inhibition	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-phenylprop-2-enoate	-	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 2,4-dihydroxybenzoate	mixed-type inhibition	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,4,5-trihydroxybenzoate	-	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,4-dihydroxybenzoate	-	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,5-dihydroxybenzoate	-	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3-hydroxybenzoate	-	Agaricus bisporus
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 4-hydroxybenzoate	-	Agaricus bisporus
kojic acid	-	Agaricus bisporus
additional information	carvacrol derivatives as mushroom tyrosinase inhibitors, synthesis, kinetics mechanism and molecular docking studies using crystal structure of mushroom tyrosinase, PDB ID 2Y9X, overview	Agaricus bisporus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cu2+	a copper-containing enzyme	Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 L-dopa + O2	Agaricus bisporus	-	2 dopaquinone + 2 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	C7FF04	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Agaricus bisporus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 L-dopa + O2	-	Agaricus bisporus	2 dopaquinone + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
mushroom tyrosinase	-	Agaricus bisporus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Agaricus bisporus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.8	-	assay at	Agaricus bisporus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	inhibition kinetic analysis and mechanism, overview	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000167	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(2,4-dihydroxyphenyl)prop-2-enoate
0.0065	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate
0.0067	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 2,4-dihydroxybenzoate
0.0067	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate
0.0077	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-phenylprop-2-enoate
0.0149	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3-hydroxybenzoate
0.0149	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 4-hydroxybenzoate
0.0159	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,4-dihydroxybenzoate
0.0652	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,4,5-trihydroxybenzoate
0.0938	-	pH 6.8, 25°C	Agaricus bisporus	2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,5-dihydroxybenzoate

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Release 2023.1 (January 2023)