Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.18.1 extracted from

  • Chai, W.M.; Wang, R.; Wei, M.K.; Zou, Z.R.; Deng, R.G.; Liu, W.S.; Peng, Y.Y.
    Proanthocyanidins extracted from Rhododendron pulchrum leaves as source of tyrosinase inhibitors structure, activity, and mechanism (2015), PLoS ONE, 10, e0145483 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
additional information proanthocyanidins extracted from Rhododendron pulchrum fresh leaves, collected from the campus of Jiangxi Normal University (Nanchang, China) in June 2011, are a source of tyrosinase inhibitors, structure, activity, and mechanism, mass spectrometric analysis, overview. Inhibition of monophenolase and diphenolase activity of mushroom tyosinase. Molecular docking of tyrosinase with the ligands using the structure of the oxy tyrosinase from Streptomyces castaneoglobisporus as the initial model for docking simulations Agaricus bisporus
procyanidin
-
 Agaricus bisporus
prodelphindin
-
 Agaricus bisporus
propelargonidin
-
 Agaricus bisporus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ required for catalysis, binuclear copper center type 3 Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?
tyrosine + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?
catechin + O2
-
 Agaricus bisporus ?
-
 ?
catechin dimer + O2
-
 Agaricus bisporus ?
-
 ?
catechin trimer + O2
-
 Agaricus bisporus ?
-
 ?
epicatechin + O2
-
 Agaricus bisporus ?
-
 ?
additional information the reactivity, the monomer (catechin/epicatechin) or oligomer (e.g. dimer, trimer) existing in Rhododendron pulchrum proanthocyanidins can take the place of 3,4-dihydroxyphenylalanine Agaricus bisporus ?
-
 ?
tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
mushroom tyrosinase
-
 Agaricus bisporus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Agaricus bisporus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information steady-state inhibition kinetics Agaricus bisporus

General Information

General Information Comment Organism
additional information tyrosinase needs 3,4-dihydroxyphenylalanine to start its monophenol oxidase activity, because of the necessity to reduce Cu2+ to Cu+ because only then the binuclear copper center type 3 of tyrosinase can bind dioxygen to oxidize tyrosine Agaricus bisporus