Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxyanisole | can also act as enzyme substrate | Agaricus bisporus | |
oxyresveratrol | a stilbenoid and reversible, non-competitive, and strong inhibitor of tyrosinase, is proposed as skin-whitening and anti-browning agent, can also act as enzyme substrate | Agaricus bisporus | |
resveratrol | can also act as enzyme substrate | Agaricus bisporus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics | Agaricus bisporus | |
0.00865 | - |
oxyresveratrol | pH 7.0, 25°C | Agaricus bisporus | |
0.08 | - |
4-hydroxyanisole | pH 7.0, 25°C | Agaricus bisporus | |
0.21 | - |
L-tyrosine | pH 7.0, 25°C | Agaricus bisporus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | a copper-containing enzyme | Agaricus bisporus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Agaricus bisporus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyanisole + O2 | - |
Agaricus bisporus | ? | - |
? | |
L-tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
oxyresveratrol + O2 | tyrosinase hydroxylates the oxyresveratrol to an o-diphenol and oxidizes the latter to an o-quinone, which finally isomerizes to p-quinone. For these reactions to take place the presence of the Eox (oxy-tyrosinase) form is necessary, analysis of the catalytic mechanism, overview. The compound can also act as inhibitor of tyrosinase | Agaricus bisporus | ? | - |
? | |
resveratrol + O2 | - |
Agaricus bisporus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mushroom tyrosinase | - |
Agaricus bisporus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Agaricus bisporus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5.39 | - |
oxyresveratrol | pH 7.0, 25°C | Agaricus bisporus | |
7.9 | - |
L-tyrosine | pH 7.0, 25°C | Agaricus bisporus | |
184.2 | - |
4-hydroxyanisole | pH 7.0, 25°C | Agaricus bisporus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
pH 7.0, 25°C | Agaricus bisporus | oxyresveratrol |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
33 | - |
L-tyrosine | pH 7.0, 25°C | Agaricus bisporus | |
620 | - |
oxyresveratrol | pH 7.0, 25°C | Agaricus bisporus | |
2300 | - |
4-hydroxyanisole | pH 7.0, 25°C | Agaricus bisporus |