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Literature summary for 1.14.18.1 extracted from
- Design, synthesis, kinetic mechanism and molecular docking studies of novel 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers (2017), Eur. J. Med. Chem., 141, 273-281 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-pentanoyl-3-(2,3-dichlorophenyl)thiourea | - |
Agaricus bisporus |  |
| 1-pentanoyl-3-(2,4,6-trimethylphenyl)thiourea | - |
Agaricus bisporus | |
| 1-pentanoyl-3-(2,4-dinitrophenyl)thiourea | - |
Agaricus bisporus | |
| 1-pentanoyl-3-(2,6-dibromo-4-fluorophenyl)thiourea | - |
Agaricus bisporus | |
| 1-pentanoyl-3-(3-nitrophenyl)thiourea | - |
Agaricus bisporus | |
| 1-pentanoyl-3-(4-bromo-2-fluorophenyl)thiourea | - |
Agaricus bisporus | |
| 1-pentanoyl-3-(4-bromophenyl)thiourea | - |
Agaricus bisporus | |
| 1-pentanoyl-3-(4-chlorophenyl)thiourea | - |
Agaricus bisporus | |
| 1-pentanoyl-3-(4-methoxyphenyl)thiourea | noncompetitive inhibition, docking interaction analysis between 1-pentanoyl-3-(4-methoxyphenyl)thiourea and mushroom tyrosinase | Agaricus bisporus | |
| 1-pentanoyl-3-(4-nitrophenyl)thiourea | - |
Agaricus bisporus | |
| kojic acid | - |
Agaricus bisporus | |
| additional information | design, synthesis, kinetic mechanism, and molecular docking studies of 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers, structure activity relationships, overview | Agaricus bisporus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Agaricus bisporus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mushroom tyrosinase | - |
Agaricus bisporus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Agaricus bisporus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Agaricus bisporus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Agaricus bisporus | |
| 0.0011 | 0.0016 | 1-pentanoyl-3-(4-methoxyphenyl)thiourea | pH 6.8, 25°C | Agaricus bisporus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0016 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(4-methoxyphenyl)thiourea | |
| 0.0023 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(4-chlorophenyl)thiourea | |
| 0.0034 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(4-bromophenyl)thiourea | |
| 0.0065 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(4-bromo-2-fluorophenyl)thiourea | |
| 0.0078 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(2,3-dichlorophenyl)thiourea | |
| 0.008 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(4-nitrophenyl)thiourea | |
| 0.0101 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(2,4-dinitrophenyl)thiourea | |
| 0.0166 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(3-nitrophenyl)thiourea | |
| 0.0195 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(2,6-dibromo-4-fluorophenyl)thiourea | |
| 0.0197 | - |
pH 6.8, 25°C | Agaricus bisporus | 1-pentanoyl-3-(2,4,6-trimethylphenyl)thiourea | |
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