Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate | mixed-type inhibition | Agaricus bisporus | |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate | reversible, mixed-type inhibition | Agaricus bisporus | |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 2,4-dihydroxybenzoate | mixed-type inhibition | Agaricus bisporus | |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 3,4-dihydroxybenzoate | - |
Agaricus bisporus | |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 3,5-dihydroxybenzoate | - |
Agaricus bisporus | |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 4-hydroxybenzoate | - |
Agaricus bisporus | |
4-formyl-2-methoxyphenyl (4-methylpiperazin-1-yl)acetate | reversible, non-competitive inhibition | Agaricus bisporus | |
4-formyl-2-methoxyphenyl (4-phenylpiperazin-1-yl)acetate | - |
Agaricus bisporus | |
4-formyl-2-methoxyphenyl chloroacetate | - |
Agaricus bisporus | |
arbutine | clinically used tyrosinase inhibitor | Agaricus bisporus | |
ascorbic acid | - |
Agaricus bisporus | |
glabridin | clinically used tyrosinase inhibitor | Agaricus bisporus | |
kaempferol | clinically used tyrosinase inhibitor | Agaricus bisporus | |
kojic acid | clinically used tyrosinase inhibitor | Agaricus bisporus | |
additional information | design, synthesis (by incorporating heterocyclic piperazine ring), and inhibitory activity of vanillin derivatives against tyrosinase, molecular docking analysis using the tyrosinase structure PDB ID 2ZWE, overview | Agaricus bisporus | |
oxyresveratrol | clinically used tyrosinase inhibitor | Agaricus bisporus | |
p-coumaric acid | clinically used tyrosinase inhibitor | Agaricus bisporus | |
Vanillin | - |
Agaricus bisporus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-dopa + O2 | Agaricus bisporus | - |
2 dopaquinone + 2 H2O | - |
? | |
tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Agaricus bisporus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-dopa + O2 | - |
Agaricus bisporus | 2 dopaquinone + 2 H2O | - |
? | |
tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mushroom tyrosinase | - |
Agaricus bisporus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Agaricus bisporus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetic analysis, overview | Agaricus bisporus | |
0.013 | - |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate | pH 6.8, 25°C | Agaricus bisporus | |
0.041 | - |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate | pH 6.8, 25°C | Agaricus bisporus | |
0.06 | - |
4-formyl-2-methoxyphenyl (4-phenylpiperazin-1-yl)acetate | pH 6.8, 25°C | Agaricus bisporus | |
0.065 | - |
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 2,4-dihydroxybenzoate | pH 6.8, 25°C | Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0161 | - |
pH 6.8, 25°C | Agaricus bisporus | 2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate | |
0.0216 | - |
pH 6.8, 25°C | Agaricus bisporus | 4-formyl-2-methoxyphenyl (4-methylpiperazin-1-yl)acetate | |
0.0309 | - |
pH 6.8, 25°C | Agaricus bisporus | 2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate | |
0.0426 | - |
pH 6.8, 25°C | Agaricus bisporus | 2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 2,4-dihydroxybenzoate | |
0.0598 | - |
pH 6.8, 25°C | Agaricus bisporus | 2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 3,5-dihydroxybenzoate | |
0.0789 | - |
pH 6.8, 25°C | Agaricus bisporus | 4-formyl-2-methoxyphenyl chloroacetate | |
0.1014 | - |
pH 6.8, 25°C | Agaricus bisporus | 4-formyl-2-methoxyphenyl (4-phenylpiperazin-1-yl)acetate | |
0.1569 | - |
pH 6.8, 25°C | Agaricus bisporus | 2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 3,4-dihydroxybenzoate | |
0.2012 | - |
pH 6.8, 25°C | Agaricus bisporus | 2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 4-hydroxybenzoate |