Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Hydroxybenzyl alcohol | the compound is a substrate and an inhibitor for tyrosinase, 39% inhibition at 1.5 mM | Agaricus bisporus | |
additional information | true inhibitors of tyrosinase diminish the rate of action of the enzyme when it acts on either of its physiological substrates, L-tyrosine (monophenolase activity) or L-dopa (diphenolase activity) | Agaricus bisporus | |
phenylacetic acid | - |
Agaricus bisporus | |
phloretin | the compound is a substrate and an inhibitor for tyrosinase, 63% inhibition at 0.2 mM | Agaricus bisporus | |
phloridzin | the compound is a substrate and an inhibitor for tyrosinase, 53% inhibition at 0.15 mM | Agaricus bisporus | |
tyrosol | the compound is a substrate and an inhibitor for tyrosinase, 18% inhibition at 1.5 mM | Agaricus bisporus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | a copper-containing enzyme | Agaricus bisporus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-dopa + O2 | Agaricus bisporus | - |
2 dopaquinone + 2 H2O | - |
? | |
tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 L-dopa + O2 = 2 dopaquinone + 2 H2O | mechanism of tyrosinase on monophenols and o-diphenol, overview | Agaricus bisporus | |
L-tyrosine + O2 = dopaquinone + H2O | mechanism of tyrosinase on monophenols and o-diphenol, overview | Agaricus bisporus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Agaricus bisporus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-dopa + O2 | - |
Agaricus bisporus | 2 dopaquinone + 2 H2O | - |
? | |
4-hydroxybenzyl alcohol + O2 | the compound is a substrate and an inhibitor for tyrosinase | Agaricus bisporus | ? | - |
? | |
phloretin + O2 | the compound is a substrate and an inhibitor for tyrosinase | Agaricus bisporus | ? | - |
? | |
phloridzin + O2 | the compound is a substrate and an inhibitor for tyrosinase | Agaricus bisporus | ? | - |
? | |
tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
tyrosol + O2 | the compound is a substrate and an inhibitor for tyrosinase | Agaricus bisporus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mushroom tyrosinase | - |
Agaricus bisporus |
General Information | Comment | Organism |
---|---|---|
physiological function | tyrosinase is a copper-containing enzyme widely distributed in nature, where it catalyses two types of reaction: (a) the ortho-hydroxylation of monophenols (L-tyrosine) to o-diphenols (L-dopa), monophenolase activity, and (b) the oxidation of o-diphenols (L-dopa) to o-quinones (L-dopaquinone), diphenolase activity. Both types of reaction require molecular oxygen as the second substrate of the enzyme. The o-dopaquinone produced from L-tyrosine and L-dopa rapidly evolves to dopachrome | Agaricus bisporus |