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Literature summary for 1.14.18.1 extracted from

  • Takahashi, T.; Miyazawa, M.
    Tyrosinase inhibitory activities of cinnamic acid analogues (2010), Pharmazie, 65, 913-918.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,4-dimethoxycinnamic acid 2.5% inhibition at 0.33 mM Agaricus bisporus
3,4-dimethoxydihydrocinnamic acid 20.2% inhibition at 1 mM Agaricus bisporus
4-coumaric acid 74.4% inhibition at 0.33 mM Agaricus bisporus
4-methoxycinnamic acid 55.2% inhibition at 1 mM Agaricus bisporus
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
-
Agaricus bisporus
arbutin
-
Agaricus bisporus
caffeic acid 6.6% inhibition at 1 mM Agaricus bisporus
Cinnamic acid 49.3% inhibition at 1 mM Agaricus bisporus
dihydro-4-coumaric acid 19.6% inhibition at 1 mM Agaricus bisporus
dihydro-4-methoxycinnamic acid 46.4% inhibition at 1 mM Agaricus bisporus
dihydrocaffeic acid 2.7% inhibition at 1 mM Agaricus bisporus
dihydrocinnamic acid 40.5% inhibition at 1 mM Agaricus bisporus
dihydroferulic acid 17.9% inhibition at 1 mM Agaricus bisporus
dihydroisoferulic acid 60.6% inhibition at 0.33 mM Agaricus bisporus
dihydrosinapic acid 22.6% inhibition at 1 mM Agaricus bisporus
ferulic acid 3.3% inhibition at 0.33 mM Agaricus bisporus
isoferulic acid 77.8% inhibition at 0.33 mM Agaricus bisporus
Sinapic acid 1.6% inhibition at 1 mM Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-DOPA + O2 Agaricus bisporus
-
dopaquinone + H2O
-
?
L-tyrosine + O2 Agaricus bisporus
-
L-DOPA + H2O
-
?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2
-
Agaricus bisporus dopaquinone + H2O
-
?
L-tyrosine + O2
-
Agaricus bisporus L-DOPA + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosinase
-
Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0516
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
0.1149
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus isoferulic acid
0.1156
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 4-coumaric acid
0.1957
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydroisoferulic acid
0.2105
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus arbutin
0.8617
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 4-methoxycinnamic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus caffeic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus ferulic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus Cinnamic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus Sinapic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 3,4-dimethoxycinnamic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydrocaffeic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydrocinnamic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydro-4-coumaric acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydro-4-methoxycinnamic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydroferulic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 3,4-dimethoxydihydrocinnamic acid
1
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydrosinapic acid