Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.18.1 extracted from

  • Li, Z.C.; Chen, L.H.; Yu, X.J.; Hu, Y.H.; Song, K.K.; Zhou, X.W.; Chen, Q.X.
    Inhibition kinetics of chlorobenzaldehyde thiosemicarbazones on mushroom tyrosinase (2010), J. Agric. Food Chem., 58, 12537-12540.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
2-chlorobenzaldehyde thiosemicarbazone exhibits significant inhibitory potency on both monophenolase activity and diphenolase activity of tyrosinase, reversible noncompetitive inhibitor Agaricus bisporus
4-chlorobenzaldehyde thiosemicarbazone exhibits significant inhibitory potency on both monophenolase activity and diphenolase activity of tyrosinase, reversible mixed-type inhibitor Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2 diphenolase activity Agaricus bisporus dopaquinone + H2O
-
 ?
L-tyrosine + O2 monophenolase activity Agaricus bisporus L-DOPA + H2O
-
 ?

Synonyms

Synonyms Comment Organism
monophenol, o-diphenol:oxygen oxidoreductase
-
 Agaricus bisporus
tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0012
-
 2-chlorobenzaldehyde thiosemicarbazone in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
0.00125
-
 4-chlorobenzaldehyde thiosemicarbazone in 5 0mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00122
-
 using L-Dopa as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus 2-chlorobenzaldehyde thiosemicarbazone
0.00182
-
 using L-Dopa as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus 4-chlorobenzaldehyde thiosemicarbazone
0.0067
-
 using L-tyrosine as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus 4-chlorobenzaldehyde thiosemicarbazone
0.0154
-
 using L-tyrosine as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus 2-chlorobenzaldehyde thiosemicarbazone