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Literature summary for 1.14.18.1 extracted from

  • Abu Ubeid, A.; Zhao, L.; Wang, Y.; Hantash, B.M.
    Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase (2009), J. Invest. Dermatol., 129, 2242-2249.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hydroquinone
-
Agaricus bisporus
hydroquinone
-
Homo sapiens
KFEKKFEK
-
Agaricus bisporus
L-Pro-L-Leu-Gly
-
Agaricus bisporus
additional information not inhibited by VLLK and KFEFKFEF Agaricus bisporus
RADSRADC
-
Agaricus bisporus
RADSRADC 25% inhibition at 0.1 mM Homo sapiens
SFLLRN
-
Agaricus bisporus
YRSRKYSSWY
-
Agaricus bisporus
YRSRKYSSWY 35% inhibition at 0.1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
melanocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2
-
Homo sapiens dopaquinone + H2O
-
?
L-DOPA + O2
-
Agaricus bisporus dopaquinone + H2O
-
?
L-tyrosine + O2
-
Homo sapiens L-DOPA + H2O
-
?
L-tyrosine + O2
-
Agaricus bisporus L-DOPA + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosinase
-
Homo sapiens
tyrosinase
-
Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.04
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C Agaricus bisporus YRSRKYSSWY
0.123
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C Agaricus bisporus RADSRADC
2.73
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C Agaricus bisporus L-Pro-L-Leu-Gly
3.6
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C Agaricus bisporus KFEKKFEK
8
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C Agaricus bisporus SFLLRN