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Literature summary for 1.14.18.1 extracted from

  • Ullah, F.; Hussain, H.; Hussain, J.; Bukhari, I.A.; Khan, M.T.; Choudhary, M.I.; Gilani, A.H.; Ahmad, V.U.
    Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum (2007), Phytother. Res., 21, 1076-1081.
    View publication on PubMed

Application

Application Comment Organism
drug development tyrosinase inhibitors can be clinically useful for the treatment of some dermatological disorders associated with melanin hyperpigmentation Agaricus bisporus

Inhibitors

Inhibitors Comment Organism Structure
2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus
3beta, 23, 24-trihydroxyolean-12-en-28-oic acid pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus
arjungenin pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus
arjunilic acid pentacyclic triterpene extracted from Rhododendron collettianum, most potent inhibitor, have potential to be used for the treatment of hyperpigmentation associated with the high production of melanocytes Agaricus bisporus
bayogenin pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus
betulinic acid pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus
erythrodiol pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus
kojic acid used as a positive control Agaricus bisporus
L-mimosine used as a positive control Agaricus bisporus
maslinic acid pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus
methyl arjunolate pentacyclic triterpene extracted from Rhododendron collettianum Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dopa + 1/2 O2
-
Agaricus bisporus L-dopaquinone + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosinase
-
Agaricus bisporus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
tyrosinase inhibition assay at Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
-
Agaricus bisporus arjunilic acid
0.0011
-
-
Agaricus bisporus bayogenin
0.00112
-
-
Agaricus bisporus 2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid
0.0017
-
-
Agaricus bisporus maslinic acid
0.00214
-
-
Agaricus bisporus betulinic acid
0.002345
-
-
Agaricus bisporus methyl arjunolate
0.00312
-
-
Agaricus bisporus erythrodiol
0.00368
-
-
Agaricus bisporus L-mimosine
0.006577
-
-
Agaricus bisporus arjungenin
0.01102
-
-
Agaricus bisporus 3beta, 23, 24-trihydroxyolean-12-en-28-oic acid
0.01667
-
-
Agaricus bisporus kojic acid