Application | Comment | Organism |
---|---|---|
drug development | inhibitor 1-hydroxy-3-phenylurea is a promising candidate for preclinical drug development for skin hyperpigmentation application | Agaricus bisporus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2,4-dimethoxyphenyl)-3-hydroxyurea | - |
Agaricus bisporus | |
1-(4-bromophenyl)-3-hydroxyurea | - |
Agaricus bisporus | |
1-(4-butoxyphenyl)-3-hydroxyurea | - |
Agaricus bisporus | |
1-hydroxy-1,3-dimethyl-3-phenylurea | - |
Agaricus bisporus | |
1-hydroxy-1-methyl-3-(4-nitrophenyl)urea | - |
Agaricus bisporus | |
1-hydroxy-1-methyl-3-phenylurea | - |
Agaricus bisporus | |
1-hydroxy-3-(4-hydroxyphenyl)urea | - |
Agaricus bisporus | |
1-hydroxy-3-(4-methoxyphenyl)urea | - |
Agaricus bisporus | |
1-hydroxy-3-(4-nitrophenyl)urea | - |
Agaricus bisporus | |
1-hydroxy-3-phenylthiourea | - |
Agaricus bisporus | |
1-hydroxy-3-phenylurea | also retains a substantial potency in cell culture by reducing pigment synthesis by 78% | Agaricus bisporus | |
1-hydroxy-3-[4-(trifluoromethyl)phenyl]urea | - |
Agaricus bisporus | |
1-methoxy-3-(4-nitrophenyl)thiourea | - |
Agaricus bisporus | |
1-methoxy-3-naphthalen-2-ylthiourea | - |
Agaricus bisporus | |
1-methoxy-3-phenylurea | - |
Agaricus bisporus | |
1-[4-(benzyloxy)phenyl]-3-hydroxyurea | - |
Agaricus bisporus | |
1-[[tert-butyl(dimethyl)silyl]oxy]-3-phenylurea | - |
Agaricus bisporus | |
3-(4-bromophenyl)-1-hydroxy-1-methylurea | - |
Agaricus bisporus | |
3-hydroxy-1-methyl-1-phenylurea | - |
Agaricus bisporus | |
3-methoxy-1-methyl-1-phenylurea | - |
Agaricus bisporus | |
hydroquinone | - |
Agaricus bisporus | |
kojic acid | - |
Agaricus bisporus | |
additional information | NHOH moiety is important for tyrosinase inhibition | Agaricus bisporus | |
N',N'''-benzene-1,4-diylbis(1-hydroxyurea) | - |
Agaricus bisporus | |
N-hydroxy-N-(phenylcarbamoyl)acetamide | - |
Agaricus bisporus | |
N-phenylthiourea | PTU induces a strong inhibition of the tyrosinase activity | Agaricus bisporus | |
N-phenylurea | - |
Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 values for N-phenylurea, 1-(2,4-dimethoxyphenyl)-3-hydroxyurea, 1-(4-butoxyphenyl)-3-hydroxyurea, 3-(4-bromophenyl)-1-hydroxy-1-methylurea, 1-methoxy-3-phenylurea, 1-hydroxy-1-methyl-3-phenylurea, 1-hydroxy-1,3-dimethyl-3-phenylurea, 3-methoxy-1-methyl-1-phenylurea, 1-hydroxy-3-phenylthiourea, 1-methoxy-3-(4-nitrophenyl)thiourea are above 1 mM | Agaricus bisporus | additional information | |
0.00029 | - |
- |
Agaricus bisporus | 1-hydroxy-3-phenylurea | |
0.0018 | - |
- |
Agaricus bisporus | N-phenylthiourea | |
0.0026 | - |
- |
Agaricus bisporus | 1-hydroxy-3-(4-nitrophenyl)urea | |
0.0027 | - |
- |
Agaricus bisporus | 1-(4-bromophenyl)-3-hydroxyurea | |
0.0043 | - |
- |
Agaricus bisporus | 1-hydroxy-3-[4-(trifluoromethyl)phenyl]urea | |
0.0063 | - |
- |
Agaricus bisporus | 1-[4-(benzyloxy)phenyl]-3-hydroxyurea | |
0.016 | - |
- |
Agaricus bisporus | 3-hydroxy-1-methyl-1-phenylurea | |
0.026 | - |
- |
Agaricus bisporus | 1-methoxy-3-naphthalen-2-ylthiourea | |
0.027 | - |
- |
Agaricus bisporus | N',N'''-benzene-1,4-diylbis(1-hydroxyurea) | |
0.032 | - |
- |
Agaricus bisporus | 1-hydroxy-3-(4-methoxyphenyl)urea | |
0.037 | - |
- |
Agaricus bisporus | hydroquinone | |
0.041 | - |
- |
Agaricus bisporus | 1-hydroxy-3-(4-hydroxyphenyl)urea | |
0.07 | - |
- |
Agaricus bisporus | 1-[[tert-butyl(dimethyl)silyl]oxy]-3-phenylurea | |
0.075 | - |
- |
Agaricus bisporus | kojic acid | |
0.17 | - |
- |
Agaricus bisporus | N-hydroxy-N-(phenylcarbamoyl)acetamide | |
0.77 | - |
- |
Agaricus bisporus | 1-hydroxy-1-methyl-3-(4-nitrophenyl)urea |