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Literature summary for 1.14.18.1 extracted from
- Inhibitory effect of p-hydroxybenzyl alcohol on tyrosinase activity and melanogenesis (2007), Biol. Pharm. Bull., 30, 1135-1139.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | results of low cytotoxicity, high inhibition of melanin synthesis and lack of effect on gene expression suggest that p-hydroxybenzyl alcohol can be a potential agent for skin lightening to be used in cosmetic products | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arbutin | - |
Agaricus bisporus |  |
| hydroquinone | - |
Agaricus bisporus | |
| kojic acid | - |
Agaricus bisporus | |
| p-hydroxybenzyl alcohol | 4HBA, inhibitory effect on tyrosinase activity and melanogenesis. As the concentration of p-hydroxybenzyl alcohol increases, the enzyme activity rapidly decreases. Results indicate that the tyrosinase binds to the p-hydroxybenzyl alcohol and induces the enzyme conformation changes, and then causes total loss of the enzyme | Agaricus bisporus | |
| p-hydroxybenzyl alcohol | p-hydroxybenzyl alcohol, inhibitory effect on tyrosinase activity and melanogenesis. p-hydroxybenzyl alcohol exhibits an inhibitory effect on melanogenesis in mouse melanocytes at noncytotoxic concentrations. The results indicate that no significant difference is observed in tyrosinase gene expression between the p-hydroxybenzyl alcohol-treated and non-treated cells. Thus, it is concluded that no repression of tyrosinase gene is induced by p-hydroxybenzyl alcohol | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-16 cell | - |
Mus musculus | - |
| commercial preparation | - |
Agaricus bisporus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
mushroom tyrosinase solution 40.0 units/ml | Agaricus bisporus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? | |
| L-tyrosine + O2 + AH2 | - |
Agaricus bisporus | L-dopa + H2O + A | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| monophenol monooxygenase | - |
Mus musculus |
| monophenol monooxygenase | - |
Agaricus bisporus |
| tyrosinase | - |
Mus musculus |
| tyrosinase | - |
Agaricus bisporus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Mus musculus |
| 6.8 | - |
assay at | Agaricus bisporus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0916 | - |
- |
Agaricus bisporus | hydroquinone | |
| 0.3292 | - |
- |
Agaricus bisporus | arbutin | |
| 0.3506 | - |
- |
Agaricus bisporus | p-hydroxybenzyl alcohol | |
| 0.3881 | - |
- |
Agaricus bisporus | kojic acid | |
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