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Literature summary for 1.14.18.1 extracted from
- Potent tyrosinase inhibitors from Trifolium balansae (2006), Nat. Prod. Res., 20, 665-670.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| campestrol | isolated from Trifolium balansae, NMR structure identification, IC50: 0.00890 mM | Agaricus bisporus |  |
| kojic acid | IC50: 0.01667 mM | Agaricus bisporus | |
| L-mimosine | IC50: 0.00368 mM | Agaricus bisporus | |
| additional information | no inhibition by phythyl-1-hexanoate and pentacosanol, both isolated and identified from Trifolium balansae | Agaricus bisporus | |
| stigmast-5-ene-3beta,26-diol | isolated from Trifolium balansae, NMR structure identification, IC50: 0.00239 mM | Agaricus bisporus | |
| stigmast-5-ene-3beta-ol | isolated from Trifolium balansae, NMR structure identification, IC50: 0.00525 mM | Agaricus bisporus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | copper-containing enzyme | Agaricus bisporus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| catecholase | - |
Agaricus bisporus |
| More | cf. EC 1.10.3.1 | Agaricus bisporus |
| tyrosinase | - |
Agaricus bisporus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Agaricus bisporus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Agaricus bisporus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00239 | - |
isolated from Trifolium balansae, NMR structure identification, IC50: 0.00239 mM | Agaricus bisporus | stigmast-5-ene-3beta,26-diol | |
| 0.00368 | - |
IC50: 0.00368 mM | Agaricus bisporus | L-mimosine | |
| 0.00525 | - |
isolated from Trifolium balansae, NMR structure identification, IC50: 0.00525 mM | Agaricus bisporus | stigmast-5-ene-3beta-ol | |
| 0.0089 | - |
isolated from Trifolium balansae, NMR structure identification, IC50: 0.00890 mM | Agaricus bisporus | campestrol | |
| 0.01667 | - |
IC50: 0.01667 mM | Agaricus bisporus | kojic acid | |
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