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Literature summary for 1.14.17.3 extracted from

  • Sharma, S.D.; Raghuraman, G.; Lee, M.S.; Prabhakar, N.R.; Kumar, G.K.
    Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing (2009), J. Appl. Physiol., 106, 12-19.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
N-Dan-Tyr-Val-Gly PHM activity in the soluble fraction of control and intermittent hypoxia brain stem ectracts Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
PHM, proteolytic processed, determined by SDS-PAGE and Western blot analysis Rattus norvegicus
42000
-
PHM, determined by SDS-PAGE and Western blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PAM is the rate-limiting enzyme for the generation of carboxy-terminal alpha-amidated neuropeptides ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain stem
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000000112
-
PHM activity, normoxia, medulla, dorsal Rattus norvegicus
0.000000155
-
PAM activity, normoxia, control Rattus norvegicus
0.0000002
-
PHM activity, normoxia, medulla, ventral Rattus norvegicus
0.000000202
-
PHM activity, normoxia, control Rattus norvegicus
0.000000207
-
PAM activity, continuous hypobaric hypoxia, 10 days Rattus norvegicus
0.000000222
-
PHM activity, normoxia, pons, ventral Rattus norvegicus
0.000000268
-
PAM activity, intermittent hypoxia, 1 day Rattus norvegicus
0.000000298
-
PHM activity, intermittent hypoxia, 1 day Rattus norvegicus
0.000000312
-
PHM activity, intermittent hypoxia, medulla, dorsal Rattus norvegicus
0.000000315
-
PHM activity, continuous hypobaric hypoxia, 10 days Rattus norvegicus
0.000000578
-
PHM activity, intermittent hypoxia, 3 days Rattus norvegicus
0.000000648
-
PHM activity, intermittent hypoxia, 10 days Rattus norvegicus
0.00000066
-
PAM activity, intermittent hypoxia, 3 days Rattus norvegicus
0.000000667
-
PHM activity, normoxia, pons, dorsal Rattus norvegicus
0.0000008
-
PHM activity, intermittent hypoxia, medulla, ventral Rattus norvegicus
0.000000888
-
PHM activity, intermittent hypoxia, ventral Rattus norvegicus
0.000000907
-
PAM activity, intermittent hypoxia, 10 days Rattus norvegicus
0.0000016
-
PHM activity, intermittent hypoxia, pons, dorsal Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PAM is the rate-limiting enzyme for the generation of carboxy-terminal alpha-amidated neuropeptides Rattus norvegicus ?
-
?
N-Dan-Tyr-Val-Gly + ascorbate + O2 PAM activity assay, the product is unstable and dismutates to N-Dan-Tyr-Val-NH2 and glyoxylate (EC4.3.2.5) Rattus norvegicus N-Dan-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
?

Synonyms

Synonyms Comment Organism
PAM PAM consists of O2-sensitive PHM and peptidyl-alpha-hydroxyglycine alpha-amidating lyase, PAL, activities Rattus norvegicus
peptidylglycine alpha-amidating monooxygenase
-
Rattus norvegicus
peptidylglycine alpha-hydroxylating monooxygenase
-
Rattus norvegicus
PHM
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
activity assay Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase via reactive oxygen species-mediated proteolytic processing up