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Literature summary for 1.14.17.3 extracted from
- Imino-oxy acetic acid dealkylation as evidence for an inner-sphere alcohol intermediate in the reaction catalyzed by peptidylglycine alpha-hydroxylating monooxygenase (2009), J. Am. Chem. Soc., 131, 10308-10319.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 95.37 | - |
O2 | protiated | Rattus norvegicus |  |
| 658.1 | - |
O2 | deuterated | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | - |
Rattus norvegicus | |
| Cu2+ | required | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidylglycine + ascorbate + O2 | Rattus norvegicus | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P14925 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| medullary thyroid carcinoma cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (([(1E)-phenylmethylidene]amino)oxy)acetic acid + ascorbate + O2 | non-enzymatic dealkylation yields benzaldoxime and glyoxylate | Rattus norvegicus | (2R)-hydroxy(([(1E)-phenylmethylidene]amino)oxy)ethanoic acid + ? | - |
? | |
| benzaldehyde imino-oxy acetic acid + O2 | assay at 37°C, pH 6.0 | Rattus norvegicus | benzaldoxime + glyoxylate | - |
? | |
| peptidylglycine + ascorbate + O2 | - |
Rattus norvegicus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peptidylglycine alpha-hydroxylating monooxygenase | - |
Rattus norvegicus |
| PHM | - |
Rattus norvegicus |
| type A PAM | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
| 37 | - |
activity assay | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
assay at | Rattus norvegicus |
| 6 | - |
activity assay | Rattus norvegicus |
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Release 2023.1 (January 2023)
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