Literature summary for 1.14.17.1 extracted from

Kapoor, A.; Shandilya, M.; Kundu, S.
Structural insight of dopamine beta-hydroxylase, a drug target for complex traits, and functional significance of exonic single nucleotide polymorphisms (2011), PLoS ONE, 6, e26509.

Search for more literature for 1.14.17.1

Protein Variants

Protein Variants	Comment	Organism
A318S	the mutation does not influence enzyme activity	Homo sapiens
G482R	the mutation has subsequent effect on the activity of the enzyme as it is present close to the active site	Homo sapiens
L317P	the mutation does not influence enzyme activity	Homo sapiens
R549C	the mutation causes abnormal oligomerization through non-native disulfide bond formation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
nepicastat	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
copper	contains copper	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dopamine + ascorbate + O2	Homo sapiens	-	noradrenaline + dehydroascorbate + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09172	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dopamine + ascorbate + O2	-	Homo sapiens	noradrenaline + dehydroascorbate + H2O	-	?

Synonyms

Synonyms	Comment	Organism
DBH	-	Homo sapiens
dopamine beta-hydroxylase	-	Homo sapiens

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Release 2023.1 (January 2023)