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Literature summary for 1.14.17.1 extracted from

  • Parlato, R.; Otto, C.; Tuckermann, J.; Stotz, S.; Kaden, S.; Groene, H.J.; Unsicker, K.; Schuetz, G.
    Conditional inactivation of glucocorticoid receptor gene in dopamine-beta-hydroxylase cells impairs chromaffin cell survival (2009), Endocrinology, 150, 1775-1781.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
mouse strain carrying the conditional allele of glucocorticoid receptor (GR) crossed with a transgenic mouse line expressing the Cre recombinase under the control of the DBH gene Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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Mus musculus
-

Synonyms

Synonyms Comment Organism
DBH
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Mus musculus
dopamine-beta-hydroxylase
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Mus musculus

General Information

General Information Comment Organism
malfunction in the GRDBHCre mice, glucocorticoid receptor (GR) immunoreactivity is lost in chromaffin cells but is unaltered in the cortex, which leads to the loss of the A-synthesizing enzyme phenylethanolamine-N-methyl-transferase (PNMT). GRDBHCre mutants are viable and fertile and do not appear different from control littermates. Degeneration of the adrenal medulla in young GRDBHCre mutants Mus musculus