Cloned (Comment) | Organism |
---|---|
mouse strain carrying the conditional allele of glucocorticoid receptor (GR) crossed with a transgenic mouse line expressing the Cre recombinase under the control of the DBH gene | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
DBH | - |
Mus musculus |
dopamine-beta-hydroxylase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | in the GRDBHCre mice, glucocorticoid receptor (GR) immunoreactivity is lost in chromaffin cells but is unaltered in the cortex, which leads to the loss of the A-synthesizing enzyme phenylethanolamine-N-methyl-transferase (PNMT). GRDBHCre mutants are viable and fertile and do not appear different from control littermates. Degeneration of the adrenal medulla in young GRDBHCre mutants | Mus musculus |