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Literature summary for 1.14.17.1 extracted from

  • Kvetnansky, R.; Krizanova, O.; Tillinger, A.; Sabban, E.L.; Thomas, S.A.; Kubovcakova, L.
    Regulation of gene expression of catecholamine biosynthetic enzymes in dopamine-beta-hydroxylase- and CRH-knockout mice exposed to stress (2008), Ann. N. Y. Acad. Sci., 1148, 257-268.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
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Mus musculus
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stellate ganglion
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Mus musculus
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Synonyms

Synonyms Comment Organism
DBH
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Mus musculus
dopamine-beta-hydroxylase
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Mus musculus

Expression

Organism Comment Expression
Mus musculus both in adrenal medulla and stellate ganglia, single immobilization significantly increases DBH mRNA and protein levels both in wild-type and corticotropin-releasing hormone knockout mice up

General Information

General Information Comment Organism
malfunction dopamine-beta-hydroxylase knockout mice are more sensitive to stress but survive a single 2 h restraint stress in a tube. Disruption of the DBH gene blocks the stress-induced elevation of tyrosine hydroxylase mRNA levels in adrenal medulla but increases phenylethanolamine N-methyltransferase gene expression in both adrenal medulla and stellate ganglia Mus musculus