Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.17.1 extracted from

  • Hassan, S.; Duong, B.; Kim, K.S.; Miles, M.F.
    Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase (2003), J. Biol. Chem., 278, 38860-38869.
    View publication on PubMed

Application

Application Comment Organism
medicine ethanol causes concentration- and time-dependent increase in DBH gene transcription. Protein kinase A, mitogen-activated protein kinase/extracellular signal -regulated kinase kinase, and casein kinase II inhibitors block induction of dopamine beta-hydroxylase and a large subset of ethanol-responsive genes. Ethanol regulation of dopamine beta-hydroxylase requires a functional cAMP-response element and its binding protein and may require interaction of multiple kinase pathways. These studies may have implications for behavioral responses to ethanol or mechanisms underlying ethanol-related neurological disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell SH-SY5Y-AH1861 Homo sapiens
-

Synonyms

Synonyms Comment Organism
DBH
-
Homo sapiens