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Literature summary for 1.14.17.1 extracted from
- Human plasma dopamine beta-hydroxylase. Purification and properties (1978), J. Biol. Chem., 253, 6780-6786.
General Stability
| General Stability | Organism |
|---|---|
| freezing and subsequent thawing results in rapid decrease of activity | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
ascorbate | - |
Homo sapiens |  |
| 2 | - |
tyramine | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | 4 atoms of tightly bound copper per tetramer | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 72000 | - |
4 * 72000 SDS-PAGE | Homo sapiens |
| 300000 | - |
dimeric form, SDS-PAGE | Homo sapiens |
| 610000 | - |
tetrameric form, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 0.5 M NaCl in 0.02 M sodium phosphate, pH 7.0, several weeks | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxyphenethylamine + ascorbate + O2 | - |
Homo sapiens | noradrenaline + dehydroascorbate + H2O | norepinephrine | ? | |
| tyramine + ascorbate + O2 | - |
Homo sapiens | octopamine + dehydroascorbate + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 72000 SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
pI: 5.8 | Homo sapiens |
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Release 2023.1 (January 2023)
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