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Literature summary for 1.14.16.5 extracted from

  • Watschinger, K.; Werner, E.R.
    Alkylglycerol monooxygenase (2013), IUBMB Life, 65, 366-372.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Chinese hamster ovary cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron the enzyme uses a di-iron centre for catalysis Rattus norvegicus
Iron the enzyme uses a di-iron centre for catalysis Caenorhabditis elegans
Iron the enzyme uses a di-iron centre for catalysis Danio rerio

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40500
-
x * 40500, SDS-PAGE Rattus norvegicus
40500
-
x * 40500, SDS-PAGE Caenorhabditis elegans
40500
-
x * 40500, SDS-PAGE Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2 Caenorhabditis elegans
-
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2 Danio rerio
-
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
?
lyso-alkyl-glycerol phospholipid + tetrahydrobiopterin + O2 Rattus norvegicus
-
1-O-(1-hydroxyalkyl)-sn-glycerol + 6,7-[8]-dihydrobiopterin + H2O
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2 Rattus norvegicus good substrate ?
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2 Caenorhabditis elegans good substrate ?
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2 Danio rerio good substrate ?
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Danio rerio
-
-
-
no activity in Drosophila melanogaster
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
6-aminohexyl Sepharose column chromatography, diethylaminoethyl cellulose column chromatography, sucrose density centrifugation, and hexadecylglycerol affinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
-
Caenorhabditis elegans 1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
-
Danio rerio 1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
?
1-O-pyrenedecyl-glycerol + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
1-O-pyrenedecyl-glycerol + tetrahydrobiopterin + O2
-
Caenorhabditis elegans ?
-
?
1-O-pyrenedecyl-glycerol + tetrahydrobiopterin + O2
-
Danio rerio ?
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
-
Caenorhabditis elegans ?
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
-
Danio rerio ?
-
?
lyso-alkyl-glycerol phospholipid + tetrahydrobiopterin + O2
-
Rattus norvegicus 1-O-(1-hydroxyalkyl)-sn-glycerol + 6,7-[8]-dihydrobiopterin + H2O
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2 good substrate Rattus norvegicus ?
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2 good substrate Caenorhabditis elegans ?
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2 good substrate Danio rerio ?
-
?
additional information 1-O-alkyl-sn glycerol-3-phosphate is no substrate Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
? x * 40500, SDS-PAGE Rattus norvegicus
? x * 40500, SDS-PAGE Caenorhabditis elegans
? x * 40500, SDS-PAGE Danio rerio

Synonyms

Synonyms Comment Organism
glyceryl ether monooxygenase
-
Rattus norvegicus
glyceryl ether monooxygenase
-
Caenorhabditis elegans
glyceryl ether monooxygenase
-
Danio rerio

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin dependent on Rattus norvegicus
tetrahydrobiopterin dependent on Caenorhabditis elegans
tetrahydrobiopterin dependent on Danio rerio

General Information

General Information Comment Organism
physiological function the enzyme has an anti-inflammatory action by switching off the platelet activating factor signal by irreversible degradation of its lyso form Rattus norvegicus