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Literature summary for 1.14.16.4 extracted from

  • Coyle, D.; Murphy, J.M.; Doyle, B.; ODonnell, A.M.; Gillick, J.; Puri, P.
    Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprungs-associated enterocolitis (2016), World J. Gastroenterol., 22, 4662-4672 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
enteric nervous system
-
 Homo sapiens
-
serotonergic neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

Synonyms Comment Organism
TPH2
-
 Homo sapiens
tryptophan hydroxylase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is reduced in ganglionic bowel in those affected by pre-operative Hirschsprung's-associated enterocolitis compared to those without Hirschsprung's-associated enterocolitis and healthy controls down