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Literature summary for 1.14.16.4 extracted from

  • Lambrus, B.G.; Cochet-Escartin, O.; Gao, J.; Newmark, P.A.; Collins, E.M.; Collins, J.J.
    Tryptophan hydroxylase is required for eye melanogenesis in the planarian Schmidtea mediterranea (2015), PLoS ONE, 10, e0127074 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Schmidtea mediterranea
-
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Schmidtea mediterranea
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
Schmidtea mediterranea
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Schmidtea mediterranea 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH
-
Schmidtea mediterranea
tryptophan hydroxylase
-
Schmidtea mediterranea

General Information

General Information Comment Organism
physiological function the enzyme is required for eye melanogenesis and essential for photoreceptor pigmentation after regeneration Schmidtea mediterranea