Protein Variants | Comment | Organism |
---|---|---|
P447R | the C1473G naturally occuring polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain, phenotypes, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8CGV2 | F2 hybrids of strains C57BL/6 and CC57BR | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | TPH2 | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities of genetic variants of TPH2 in strains C57BL/6 and CC57BR, and in F2 hybrids of these strains, the C7C genotype shows 2fold higher activity compared to the G/G genotype of the C1473G polymorphism, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Mus musculus |
tryptophan hydroxylase-2 | - |
Mus musculus |