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Literature summary for 1.14.16.4 extracted from

  • Kulikov, A.V.; Osipova, D.V.; Popova, N.K.
    The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain (2007), Russ. J. Genet., 43, 1408-1412.
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
P447R the C1473G naturally occuring polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Mus musculus key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8CGV2 F2 hybrids of strains C57BL/6 and CC57BR
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Source Tissue

Source Tissue Comment Organism Textmining
brain TPH2 Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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activities of genetic variants of TPH2 in strains C57BL/6 and CC57BR, and in F2 hybrids of these strains, the C7C genotype shows 2fold higher activity compared to the G/G genotype of the C1473G polymorphism, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
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Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?
L-tryptophan + tetrahydrobiopterin + O2 key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?

Synonyms

Synonyms Comment Organism
TPH2
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Mus musculus
tryptophan hydroxylase-2
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Mus musculus