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Literature summary for 1.14.16.4 extracted from

  • Bonkale, W.L.; Austin, M.C.
    3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus (2008), Neuroscience, 155, 270-276.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information administration of 3,4-methylenedioxymethamphetamine to rats induces TPH1, but affects serotonin biosynthesis and TPH enzyme activity in dorsal raphe nuclei, and it decreases SERT binding sites in the striatum, nucleus accumbens and cingulate cortex demonstrating a loss of 5-hydroxytryptamine terminals, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus isozyme TPH2 is the rate-limiting enzyme in serotonin/5-hydroxytryptamine biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain dorsal raphe nucleus, expression analysis and enzyme levels of TPH2, quantitative immunoautoradiography and in situ hybridization histochemistry, overview, activity occurs also in striatum, nucleus accumbens and cingulate cortex Rattus norvegicus
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corpus striatum
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
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Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?
L-tryptophan + tetrahydrobiopterin + O2 isozyme TPH2 is the rate-limiting enzyme in serotonin/5-hydroxytryptamine biosynthesis Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?

Synonyms

Synonyms Comment Organism
TPH2
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Rattus norvegicus
tryptophan hydroxylase 2
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Rattus norvegicus