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Literature summary for 1.14.16.4 extracted from
- Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord (2008), Neurosci. Bull., 24, 29-33.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | TPH is the rate limiting enzyme in serotonin biosynthesis, the enzyme and 5-hydroxytryptamine might be involved in exercise-induced fatigue | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spinal cord | ventral horn, enzyme expression in muscle after exercise-induced fatigue and control muscle, overview | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | TPH is the rate limiting enzyme in serotonin biosynthesis, the enzyme and 5-hydroxytryptamine might be involved in exercise-induced fatigue | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tryptophan hydroxylase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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