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Literature summary for 1.14.16.4 extracted from

  • Zill, P.; Preuss, U.W.; Koller, G.; Bondy, B.; Soyka, M.
    SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide (2007), Neuropsychopharmacology, 32, 1687-1694.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene TPH2 is located on chromosome 12q15 comprising 11 exons, DNA and amino acid determination and analysis, genotyping of a population of alcohol-dependent patients of Caucasian origin from southern Germany Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information single nucleotide polymorphism, linkage disequilibrium, and haplotype studies on 353 alcohol-dependent patients of whom 102 individuals have a history of at least one suicide attempt and 305 healthy controls with 20 single nucleotide polymorphisms covering the entire gene region of TPH2. Neither single single nucleotide polymorphism nor haplotype analysis detect significant associations with alcohol dependence and/or suicidal behavior among alcohol-dependent patients, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens the enzyme is rate-limiting in neuronal serotonin biosynthesis, disturbances of the central serotonergic system, due to genetic variations in the TPH2 gene, are involved in the pathophysiology of alcohol dependence and suicidal behavior 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9 alcohol-dependent patients of Caucasian origin from southern Germany
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Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
Homo sapiens
-
neuron
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is rate-limiting in neuronal serotonin biosynthesis, disturbances of the central serotonergic system, due to genetic variations in the TPH2 gene, are involved in the pathophysiology of alcohol dependence and suicidal behavior Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH2
-
Homo sapiens
tryptophan hydroxylase 2
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Homo sapiens