Cloned (Comment) | Organism |
---|---|
gene TPH2 is located on chromosome 12q15 comprising 11 exons, DNA and amino acid determination and analysis, genotyping of a population of alcohol-dependent patients of Caucasian origin from southern Germany | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | single nucleotide polymorphism, linkage disequilibrium, and haplotype studies on 353 alcohol-dependent patients of whom 102 individuals have a history of at least one suicide attempt and 305 healthy controls with 20 single nucleotide polymorphisms covering the entire gene region of TPH2. Neither single single nucleotide polymorphism nor haplotype analysis detect significant associations with alcohol dependence and/or suicidal behavior among alcohol-dependent patients, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | the enzyme is rate-limiting in neuronal serotonin biosynthesis, disturbances of the central serotonergic system, due to genetic variations in the TPH2 gene, are involved in the pathophysiology of alcohol dependence and suicidal behavior | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | alcohol-dependent patients of Caucasian origin from southern Germany | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is rate-limiting in neuronal serotonin biosynthesis, disturbances of the central serotonergic system, due to genetic variations in the TPH2 gene, are involved in the pathophysiology of alcohol dependence and suicidal behavior | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Homo sapiens |